Gels are widely used in our everyday lives, spanning personal care, cosmetics, oral care, food and beverages, household

products, medical supplies, electronics, and arts and crafts. Their adaptable characteristics contribute to improved product

performance, user satisfaction, and overall convenience. However, generation of microbial invasion is a common obstacle

observed on gels and its formulations. Antibiotic loaded on gels is a better alternative to chemical-based preservative for

long-term storage of gels. In this research, the gel was fabricated with two diff erent components with guar gum (GU) and

tetracycline (TC) and its antimicrobial ability was tested over a period of time. We conducted morphological analyses that

revealed a solid and rough surface on both GU and reduced sign of microbial attack on TC/GU-based gels. Identifi cation of

functional groups is observed using Fourier transform infrared (FTIR) spectroscopy that confi rms the gel is well hydrated

and make it suitable to deliver antimicrobial agents. Antimicrobial ability performed by antibiotics was tested using disc

diff usion method. The unloaded GU gel does not exhibit an observed antimicrobial property, whereas GU/TC gel reveals a

better antibacterial effi ciency on S. aureus compared to E. coli . Our fi ndings suggest that GU/TC gel can eff ectively safeguard

gels from microbial attacks during long-term storage. Furthermore, this GU/TC gel can be used as a drug transport system

for bioactive agents in biomedical applications.