Overall
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received January 12, 2024
Accepted April 4, 2024
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Loading of 4-Chloro-3-Formylcoumarin on the Potassium-Based Perylene Tetracarboxylic Acid as the Metal–Organic Framework for the Biocompatible Antimicrobial Performances
Abstract
Metal–organic frameworks (MOFs) are a unique class of porous materials formed by connecting metal ions or clusters within
the organic ligands. They have attracted substantial attention in various fi elds, including drug delivery and their potential
in addressing microbial infections. In this particular research, we accomplished the successful encapsulation of 4-chloro-
3-formylcoumarin (CFC) within potassium-based perylene tetracarboxylic acid (K 4 PTC) MOFs. Our investigation involved
characterizing this process using proton chemical shifts, affi rming the eff ective incorporation of CFC molecules within the
cavities of the MOFs. Moreover, the diff erences between MOFs that had been loaded with CFC and those that remained
unloaded are strikingly evident in scanning electron microscopy (SEM) images. These distinctions allowed us to visually
confi rm the successful loading of CFC into the MOFs. To evaluate the MOFs' antibacterial properties, we conducted experiments
involving two human pathogenic microbes. The results revealed signifi cant zones of growth inhibition corresponding
to the concentration of MOFs used, underscoring their potent antibacterial activity. In addition to these assessments, we
conducted a biofi lm assay to gauge the MOFs' eff ectiveness in countering the formation of biofi lms by these pathogens.
