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- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received June 12, 2001
Accepted July 6, 2001
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Copyright © KIChE. All rights reserved.
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Preparation of L-PLA Submicron Particles by a Continuous Supercritical Antisolvent Precipitation Process
Supercritical Fluid Research Lab., Korea Institute of Science and Technology, 39-1, Haweolgok-dong, Sungbuk-gu, Seoul 136-791, Korea 1Department of Chemical Engineering, Yonsei University, 134, Shinchon-dong, Sodaemon-ku, Seoul 120-749, Korea
Korean Journal of Chemical Engineering, January 2002, 19(1), 139-145(7), 10.1007/BF02706887
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Abstract
Submicron particles of L-polylactic acid (L-PLA) without residual solvent were prepared by a continuous supercritical antisolvent (SAS) recrystallization process. Methylene chloride (CH2Cl2) was used as a carrier solvent of L-PLA. Experiments were performed with changing process parameters such as pressure and temperature at constant concentration. Also, L-PLA initial concentrations in methylene chloride were varied from 0.3 to 4 wt%. The flow rates of CO2 and solution, which were introduced into the precipitator, and nozzle diameter were kept unchanged in all of the experiments. It was found that the SAS process gives fine tuning of particle size and particle size distribution (PSD) by simple manipulations of the process parameters. In all cases of SAS recrystallization experiments, the formed spherical fine particles with a smooth surface were non-agglomerated and free flowing. Mean particle size of the L-PLA microparticles formed was varied from 0.1 to 1 mm by means of adjusting the system pressure and/or temperature.
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References
Bleich J, Muller BW, J. Microencapsul., 13(2), 131 (1996)
Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP, Pharm. Res., 12, 1211 (1995)
Dixon DJ, Johnston KP, Bodmeier RA, AIChE J., 39, 127 (1993)
Kerc J, Srcic S, Knez Z, Sen Car-Bo zi c P, Int. J. Pharm., 182, 33 (1999)
Lefebvre AH, "Atomization and Sprays," Hemisphere, New York (1989)
Palakodaty S, York P, Pritchard J, Pharm. Res., 15, 1835 (1998)
Randolph TW, Randolph AD, Mebes M, Yeung S, Biotechnol. Prog., 9, 429 (1993)
Reverchon E, Della Porta C, Di Trolio A, Pace S, Ind. Eng. Chem. Res., 37(3), 952 (1998)
Tom JW, Lim GB, Debenedetti PG, Prudhomme RK, Am. Chem. Soc. Symp. Ser., 514, 238 (1993)
Yeo SD, Lim GB, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341 (1993)
Yeo SD, Choi JH, Lee TJ, J. Supercrit. Fluids, 16(3), 235 (2000)
Yolles S, Leafe TD, Meyer FJ, J. Pharm. Sci., 64(1), 115 (1975)
Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP, Pharm. Res., 12, 1211 (1995)
Dixon DJ, Johnston KP, Bodmeier RA, AIChE J., 39, 127 (1993)
Kerc J, Srcic S, Knez Z, Sen Car-Bo zi c P, Int. J. Pharm., 182, 33 (1999)
Lefebvre AH, "Atomization and Sprays," Hemisphere, New York (1989)
Palakodaty S, York P, Pritchard J, Pharm. Res., 15, 1835 (1998)
Randolph TW, Randolph AD, Mebes M, Yeung S, Biotechnol. Prog., 9, 429 (1993)
Reverchon E, Della Porta C, Di Trolio A, Pace S, Ind. Eng. Chem. Res., 37(3), 952 (1998)
Tom JW, Lim GB, Debenedetti PG, Prudhomme RK, Am. Chem. Soc. Symp. Ser., 514, 238 (1993)
Yeo SD, Lim GB, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341 (1993)
Yeo SD, Choi JH, Lee TJ, J. Supercrit. Fluids, 16(3), 235 (2000)
Yolles S, Leafe TD, Meyer FJ, J. Pharm. Sci., 64(1), 115 (1975)
