ISSN: 0256-1115 (print version) ISSN: 1975-7220 (electronic version)
Copyright © 2024 KICHE. All rights reserved

Articles & Issues

Language
English
Conflict of Interest
In relation to this article, we declare that there is no conflict of interest.
Publication history
Received March 7, 2024
Accepted June 4, 2024
articles This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.

Latest issues

One-Pot Preparation of Alpha-Chymotrypsin Degradable Hydrogel Micropatterns for Controlled Drug Release

Sookmyung Women’s University 1Dongduk Women’s University 2Kangwon National University 3Korea Institute of Science and Technology
ksswdf@kist.re.kr, dshin@sookmyung.ac.kr
Korean Journal of Chemical Engineering, September 2024, 41(9), 2651-2659(9), https://doi.org/10.1007/s11814-024-00205-2

Abstract

Fluorouracil (5-FU) has been the most widely used chemotherapy agent since its clinical introduction in 1957, and it continues

to form the basis of treatment for various cancers. However, due to the side eff ects of an antimetabolite, a strategy

fulfi lling stringent requirements placed on a 5-FU delivery system requires controlled and extended release of 5-FU in a

localized manner. Here, an in-situ gel-forming method for the preparation of micropatterned, α-chymotrypsin-degradable

hydrogel (PHcd) for controlled release of 5-FU is introduced. More specifi cally, methacrylated hyaluronic acid (HA) and

polyethylene glycol diacrylate (PEGDA), known for their excellent moisture retention capacity, are chosen for skin therapy.

They are crosslinked with CYKC peptide through a thiol-ene click reaction. The synthesis of the CYKC peptide and its cleavage

by α-chymotrypsin were confi rmed using high-performance liquid chromatography (HPLC). Additionally, the in vitro

release behavior was accurately monitored using the micropatterning method, demonstrating the stable immobilization and

successful sustained release of 5-FU upon the addition of α-chymotrypsin in micropatterned PHcd hydrogel. Consequently,

this micropatterned PHcd hydrogel can be considered a promising scaff old for localized and sustained delivery of cytotoxic

drugs for skin cancer treatment.

The Korean Institute of Chemical Engineers. F5, 119, Anam-ro, Seongbuk-gu, 233 Spring Street Seoul 02856, South Korea.
TEL. No. +82-2-458-3078FAX No. +82-507-804-0669E-mail : kiche@kiche.or.kr

Copyright (C) KICHE.all rights reserved.

- Korean Journal of Chemical Engineering 상단으로