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크로마토포아와 NAD Kinase로 이루어진 공역반응계의 모형화와 수치모사

Modeling and Simulation of the Coupled Reaction System Comprised of Chromatophore and NAD Kinase

HWAHAK KONGHAK, April 1982, 20(2), 113-122(10), NONE
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Abstract

크로마토포아와 NAD kinase로 구성된 공역 반응계에 대하여 수학적 모형화와 컴퓨터 수치모사를 수행하였다. 크로마토포아에 대해서는 경험적인 반응속도식을 사용하였으며 공역 반응계의 다른 촉매 성분에 대해서는 이론적으로 유도된 식들을 사용하였다. 크로마토포아와 NAD kinase로부터 완전히 분리하기가 어렵기 때문에 마이오 카이네이즈도 반응계의 구성 성분으로 포함시켰다.
반응계의 촉매 성분들의 상대적인 활성 비율이 NADP 생산에 미치는 영향도 조사되었다. 반응계의 여러 생화학 성분들의 시간에 따른 변화 추이도 수치모사 결과로부터 알 수 있었다.
실험 데이터와 컴퓨터 수치모사 결과를 비교하여 보았다.
Mathematical modeling and computer simulation were carried out on the coupled reaction system comprised of chromatophore and NAD kinase. An empirical kinetic model was used for the chromatophore whereas analytically derived models were employed for other catalytic components of the system. Myokinase was also included as a system component because of the difficulty in its complete separation from the chromatophore and NAD kinase.
The effect of the relative ratio of the catalytic activities of the system on the overall production of NADP was studied. The time course behaviour of the biochemical species of the system was also obtained from the simulation results.
Experimental data and the results of the computer simulation were compared.

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