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키토산과 가교 키토산을 이용한 경피흡수치료 시스템 개발

Development of Transdermal Therapeutic Systems using Crosslinked Chitosan and Chitosan

나재운

Nah JW

HWAHAK KONGHAK, June 1998, 36(3), 484-490(7), NONE

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Abstract

Chitin, the natural polymer has been known as harmless and innoxious material to human and been also known to be biodegradable. Chitosan was prepared by the deacetylation of chitin. The crosslinked chitosan was prepared from chitin after reaction with epichlorohydrin followed by deacetylation at C₂-position. Epidermal releasing polymeric matrix was prepared after swelling drug carriers(chitosan and crosslinked chitosan) with distilled water, and adding silver sulfadiazine and glycerine. The release behavior of drug from polymeric matrix was studied in pH 7.4 phosphate buffer solution by varying the silver sulfadiazine content, glycerine concentration, and the thickness of the matrix. The drug release time was delayed by increasing the content of silver sulfadiazine and the thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant(K) of release rate was independent upon the matrix thickness, but was proportional to the content of drug or glycerine. Thus the drug release rate at the crosslinked chitosan matrix was more delayed than at the chitosan matrix. These results indicated that the drug carriers matrix showed some potential as drug delivery systems for transdermal therapeutic applications.

Keywords

Chitosan Crosslinked Chitosan Polymeric Matrix Silver Sulfadiazine Drug Delivery System

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