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키토산 제조에서의 탈아세틸화 반응에 관한 연구
A Study on Deacetylation of Chitin for Preparation of Chitosan
HWAHAK KONGHAK, August 1998, 36(4), 496-501(6), NONE
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Abstract
키틴을 탈아세틸화하여 순수 키토산을 제조하는 반응에 있어서 알칼리 용액의 농도, 온도, 반응시간과 탈아세틸화도의 관계를 연구하여, 부분 탈아세틸화된 키토산으로부터 탈아세틸화도가 완전히 이루어진 키토산을 제조할 수 있었다. 탈아세틸화 반응에서 얻어지는 중간 생성물 키토산은 큰 분자사슬이 절단되지 않도록 단계적으로 증류수 세척에 의하여 중화시킴으로서, 최적농도와 알칼리 가수분해 반응시간에 의하여 탈아세틸화도가 높은 키토산을 제조할 수 있었다 알칼리 용액의 농도가 47%이고, 반응온도가 25-110℃인 범위에서 구한 탈아세틸화 반응의 활성화에너지는 7 kcal/mol이었다.
The relationships between the concentration of alkali solution for hydrolysis, reaction temperature, reaction time and deacetylation of chitin were studied for the preparation of pure chitosan. It was possible to prepare complete deacetylation of chitosan products from low degrees of deacetylation. The intermediate products of partially deacetylated chitosan through the deacetylation process was intermittently washed with distilled water to neutralize preventing serious degradation of molecular chain. It could be prepared the highly deacetylated chitosan by the concentration and reaction time of alkaline hydrolysis. The activation energy was presented 7 kcal/mol by the deacetylation of chitin in the range of 25-110℃ with 47% alkali solution.
Keywords
References
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Wolfrom ML, Maher GG, Chaney A, J. Org. Chem., 23, 1990 (1958)
Wolfrom ML, Shen Han TM, J. Am. Chem. Soc., 81, 1764 (1959)
Mima S, Miya M, Iwamoto R, Yoshikawa S, J. Appl. Polym. Sci., 28, 1909 (1983)
Meyer KH, Wehrli H, Helv. Chim. Acta, 20, 353 (1937)
Sannan T, Kurita K, Iwakura Y, Polym. J., 9(6), 649 (1977)
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Miya M, Iwamoto R, Yoshikawa S, Mima S, Int. J. Biol. Macromol., 2, 323 (1980)
