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Received December 2, 2003
Accepted February 5, 2004
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진동에 의한 혈관 내 폐 보조장치의 산소전달 특성
Characteristics of Oxygen Transfer in Intravascular Lung Assist Device by Vibrating
Gi-Beum Kim†
Tae-Kyu Kwon
Sam-Cheol Lee1
Seong-Jong Kim2
In-Soo Cheong3
In-Hyeog Oh4
Ki-Ju Kim
Yoon-Sup Byun5
Gyeong-Rak
Jheong
전북대학교 공과대학 생체정보공학부·전북대학교 공학연구원 공업기술연구센터, 561-756 전북 전주시 덕진구 덕진동1가 664-14 1한려대학교 물리치료학과, 545-704 전남 광양시 광양읍 덕례리 199-4 2익산대학 환경공업화학과, 570-752 전북 익산시 마동 194-5 3한국과학기술정보연구원, 561-841 전북 전주시 덕진구 팔복동1가 337-2 4(주)KT&G 중앙연구원, 561-756 전북 전주시 덕진구 덕진동1가 664-14 5호원대학교 환경화공과, 573-718 전북 군산시 임피면 월하리 727
Division of Bionics and Bioinformations, College of Engineering · The Research Center of Industrial Technology,Engineering Research Institute, Chonbuk National University, 664-14 1 Ga, Duckjin-dong, Duckjin-gu, Jeonju, Jeonbuk 561-756, Korea 1Department of Physical Therapy, Hanlyo University, 199-4, Duckrae-ri, Kwangyang-eup, Kwangyang, Chonnam 545-704, Korea 2Department of Environmental Engineering & Chemical Technology, Iksan National Collage, 194-5, Ma-dong, Ricksan, Jeonbuk 570-752, Korea 3Korea Institute of Science and Technology Information, 337-2 1 Ga, Palbok-dong, Duckjin-gu, Jeonju, Jeonbuk, 561-841, Korea 4KT&G Central Research Institute, 302, Shinsung-dong, Yusung-gu, Daejeon 305-345, Korea 5Division of Environmental & Chemical Engineering, Howon University, 727, Wolha-ri, Impi-myeon, Gunsan, Jeonbuk 573-718, Korea
kgb70@chonbuk.ac.kr
Korean Chemical Engineering Research, April 2004, 42(2), 151-162(12), NONE Epub 14 May 2004
Abstract
본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사 막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가진 주파수의 함수관계를 이용하여 기체전달을 예측할 수 있었다. 실험에 의하여 얻어진 결과는 예측 식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVALD의 기체전달을 예측할 수 있었다.
In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the gas transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.
Keywords
References
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Pearson GD, Short BL, J. Intens. Care. Med., 2, 116 (1986)
Finder NN, Tierney AJ, Hallgren R, Hayashi A, Peliowski A, Etches PC, Can. Med. Assoc. J., 146 (1992)
Campell TG, ASAIO J., 40, 109 (1994)
Fedespiel WJ, Hout MS, Hewitt TJ, Lund LW, Leinrich SA, Litwak P, Walters FR, Reeder GD, Borovetz HS, Hattler BG, ASAIO J., 43, M725 (1997)
Hewitt TJ, Hattler BG, Federspiel WJ, Annu. Biomed. Eng., 26, 166 (1998)
Vaslef SN, Mockros LF, Anderson RW, Trans. Am. Soc. Artif. Intern. Organs, 35, 660 (1989)
Federspiel WJ, Hewitt TJ, Hout MS, Walters FR, ASAIO J., 42, M435 (1996)
Federspiel WJ, Williams JL, Hattler BG, AIChE J., 42(7), 2094 (1996)
Nodelman V, Baskaran H, Ultman JS, Annals Biomed. Eng., 26, 1044 (1998)
Vaslef SN, Cook KE, Leonard RJ, Mockros LF, Anderson RW, ASAIO J., 40, M522 (1994)
Federspiel WJ, Lund LW, Bultman JA, Wanant S, Matoney J, Golob JF, Frankowski BJ, Watach M, Litwak P, Hattler BG, ASAIO J., 45, 127 (1999)
Lee SC, Kim KB, Hong SC, Kim MH, Jheong GR, J. Biomed. Eng. Res., 21(3), 311 (2000)
Mortensen JD, Trans. Am. Soc. Artif. Intern. Organs., 33, 570 (1987)
Mortensen JD, Artif. Organs, 16, 75 (1992)
Vaslef SN, Mockros LF, Anderson RW, Trans. Am. Soc. Artif. Intern. Organs, 35, 660 (1989)
Snider MT, M.T. U.S. Patent, Application, Serial No. WO 93/13,828 (1993)
http://www.eurekalert.org/pub_releases/2002-06/uomh-ual061002.php
Nodelman V, Baskaran H, Ultman JS, Annals Biomed. Eng., 26, 1044 (1998)
Vaslef SN, Mockros LF, Cook KE, Leonard RJ, Sung JC, Anderson RW, Artif. Organs, 18(11), 813 (1994)
Katoh S, Yoshida F, Chem. Eng. J., 3, 51 (1972)
McCabe WL, Smith JC, Harriott P, Unit Operation of Chemical Engineering, 5th ed., McGraw-Hill Inc., New York (1993)
Streeter VL, Wylie EB, Bedford K, Fluid Mechanics, 9th ed., McGraw-Hill, Inc., New York (1998)
Bird RB, Stewart WE, Lightfoot EN, Transport Phenomena, 2th ed., John Wiley & Sons, Inc., New York (2002)
Mulder M, Basic Principles of Membrane Technology, Kluwer Academic, Netherlands (1996)
Beek WL, Muttzell KMK, vanHeuven JW, Transport Phenomena, 2th ed., John Wiley & Sons (ASIA) PTE LTD, Singapore (1999)
Wickramasinghe SR, Kahr CM, Han BB, Biotechnol. Prog., 18(4), 867 (2002)
Kim GB, Kwon TK, Jheong GR, Lee SC, J. Biomed. Eng. Res., 24(2), 121 (2003)
Park JK, Kim GB, Kwon TK, Hong SC, Jheong GR, Lee SC, Theor. Appl. Chem. Eng., 2(2), 5070 (2002)
Kim GB, Kwon TK, Park JK, Jheong GR, Lee SC, Membrane, 13(1), 20 (2003)
Kim GB, Kwon TK, Jheong GR, J. Biomed. Eng. Res., 24(4), 293 (2003)
AAMI Standard: Cardionascular/Neurology Standards for Blood/Gas Exchanger Devices (Oxygenators); August 14 (1998)
ISO/DIS 7199 International Standard: Cardiovascular Implantants and Artificial Organs-Blood-Gas Exchangers (1996)
Nollet LML, Handbook of water analysis: Chemical Parameter's by de Medina, H.L., N.Y., Darcel Deker (2000)
Vaslef SN, Analysis and Designs of an Intravascular Lung Asisst Device, Ph.D. Dissertation (1990)
Vennard JK, Street RL, Elementary Fluid Mechanics, 6th ed., John Wiley & Sons Inc., New York (1995)
Ciuryla VT, Oxygen Diffusion in Human Blood Plasma, Ph.D. Dissertation, Northwestern University (1971)
