Articles & Issues
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- korean
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- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received December 3, 2004
Accepted December 22, 2004
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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분자각인 고분자의 제조와 분리특성
Manufacture and Separation Characteristic of MIP
Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-dong, Nam-Ku, Incheon 402-751, Korea
rowkho@inha.ac.kr
Korean Chemical Engineering Research, December 2004, 42(6), 635-645(11), NONE Epub 11 January 2005
Abstract
분자각인 기술은 사전에 결정된 선택성을 가진 분리 매체를 제조하는 기술이다. 이 기술은 효소의 구조를 연구하고 항원-항체의 작용원리 및 분석화학 등 방면에 중요한 의의를 가진다. 분석적인 분리과학에서 분자각인 고분자는 액체 크로마토그래피, 모세관 전자크로마토그래피, 모세관 전기영동, 고정상 추출, 면역효과와 선택성을 가진 센서 등 다양한 분석방법에 적용된다. 분자각인 고분자는 주로 주형분자와 기능성 단량체의 공유와 비공유의 두 가지 결합원리로 키랄 물질을 분리한다. 본 총설에서는 분자각인 고분자에 대한 원리와 제조 및 분리특성에 대하여 포괄적으로 서술하였다.
The molecular imprinting technique is a reliable technique for the preparation of materials of predetermined selectivity. It is highly significant in research of the structure of enzyme, mechanism of receptor-antibody and analytical chemistry. In analytical separation science, molecularly imprinted polymers have been applied in several analytical techniques, such as liquid chromatography, capillary electrochromatography and capillary electrophoresis, solid phase extraction, immuno-assay, and as a selective in chemical sensors. Molecular imprinted polymer for chiral separations have been prepared mainly two approaches: covalent and non-covalent binding of the template and the functional monomer. In this review article, the essential theories, synthesis, manufacture and separation characteristic of molecular imprinting technique are widely described.
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Fairhurst RE, Chassaing C, Venn RF, Mayes AG, Biosens. Bioelectron., 20, 1098 (2004)
Sellergren B, J. Chromatogr. A, 673, 133 (1994)
Wulff G, Sarhan A, Angew. Chem.-Int. Edit. Engl., 11, 341 (1972)
Wulff G, Sarhan A, Kabrocki K, Tetrahedron Lett., 14(44), 4329 (1973)
Wulff G, Poll HG, Minarik M, J. Liquid Chromatogr., 9, 385 (1986)
Wulff G, Angew. Chem.-Int. Engl., 34, 1812 (1995)
Andersson LI, O'Shanneessy DJ, Mosbach K, J. Chromatogr. A, 513, 167 (1990)
Andersson LI, Mosbach K, J. Chromatogr. A, 516, 313 (1990)
Andersson JI, Ekberg B, Mosbach K, Plenum Press, 383 (1993)
Liu XL, Liu Y, Wang JD, Shang ZH, Chin. J. Anal. Chem., 10, 1260 (2002)
Yu C, Mosbach K, J. Chromatogr. A, 888, 63 (2000)
Faihurst RE, Chassaing C, Venn RF, Mayes AG, Biosensors and Bioelectronics, 20, 1098 (2004)
Liu ZS, Wu YL, Yan C, Gao RY, Anal. Chim. Acta, 523, 243 (2004)
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Allender CJ, Brain KR, Ballatore C, Cahardc D, Siddiqui A, McGuigan C, Anal. Chim. Acta, 435, 107 (2001)
Lu Y, Li CX, Zhang HS, Liu XH, Anal. Chim. Acta, 489, 33 (2003)
Wistuba D, Schurig V, J. Chromatogr. A, 875, 255 (2000)
Ulbricht M, J. Chromatogr. B, 804, 113 (2004)
Kriz D, Mosbach K, Anal. Chim. Acta, 300, 71 (1994)
Piletsky SA, Piletska EV, Bossi A, Karim K, Lowe P, Turner APF, Biosens. Bioelectron., 16, 701 (2001)
Kempe M, Mosbach K, J. Chromatogr. A, 664, 276 (1997)
Huang XD, Qin F, Chen XM, Liu YQ, Zou HF, J. Chromatogr. B, 804, 13 (2004)
Cheng SH, Oh CY, Seo JI, Park JK, Korean J. Bioeng., 16, 115 (2001)
Mallik S, Johnson RD, Arnold FH, J. Am. Chem. Soc., 116(20), 8902 (1994)
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Rimmer S, J. Chromatogr. A, 46, 470 (1998)
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Sellergren B, J. Chromatogr. A, 906, 227 (2001)
Sellergren B, Shea KJ, J. Chromatogr. A, 635, 31 (1993)
Sellergren B, J. Chromatogr. A, 600, 29 (1995)
Shi RX, Guo CH, Zou XH, Zhu CY, Zuo YJ, Deng YD, Prog. Chem., 14(3), 182 (2002)
Moral NP, Mayes AG, Anal. Chim. Acta, 504, 15 (2004)
Ohkubo K, Urata Y, Hirota S, Funakoshi Y, Sagawa T, Usui S, Yoshinaga K, J. Mol. Catal. A-Chem., 101, L111 (1995)
Lin JM, Nakagama T, Uchiyama A, Hobo T, J. Pharmaceutical. Biomedical. Analysis., 15, 1351 (1997)
Kempe M, Mosbach K, J. Chromatogr. A, 691, 317 (1995)
Liao Y, Wang W, Wang BH, Bioorganic Chem., 26, 309 (1998)
Whitcombe MJ, Rodriguez ME, Villar P, Vulfson EN, J. Am. Chem. Soc., 117(27), 7105 (1995)
Idziak I, Benrebouh A, Analyst, 125, 1415 (2000)
Sellergren B, Anal. Chim. Acta, 66, 1578 (1994)
Sergeyeva TA, Matuschewski H, Piletsky SA, Bendig J, Schedler V, Ulbricht M, J. Chromatogr. A, 907, 89 (2001)
Zheng N, Li YZ, Chang WB, Wang ZM, Li TJ, Anal. Chim. Acta, 452, 277 (2002)
Cormack PAG, Elorza AZ, J. Chromatogr. B, 804, 173 (2004)
Haupt K, Mayes AG, Mosbach K, Anal. Chim. Acta, 70, 3936 (1998)
Andersson LI, Muller R, Vlatakis G, Mosbach K, Proc. Natl. Acod. Sci. USA, 92, 4788 (1995)
Piletsky SA, Alcock S, Turner APF, Trends Biotechnol., 19(1), 9 (2001)
Nicholls IA, Andersson LI, Mosbach K, Trends Biotechnol., 13(2), 47 (1995)
Lu Y, Li CX, Zhang HS, Liu XH, Anal. Chim. Acta, 489, 33 (2003)
Chen XX, Yue ZF, Liang SZ, Modern Chemical Industry, 23, 245 (2003)
Spivak DA, Campbell J, J. Analyst, 126, 793 (2001)
Vidyasankar S, Ru M, Arnold FH, J. Chromatogr. A, 775, 51 (1997)
Sellergren B, Shea KJ, J. Chromatogr. A, 654, 17 (1993)
Nicholls IA, Ramstrom O, Mosbach K, J. Chromatogr. A, 691, 349 (1995)
Hwang CC, Lee WC, J. Chromatogr. B, 765, 45 (2001)
Yu C, Mosbach K, J. Org. Chem., 62, 4057 (1997)
Chen YB, Kele M, Quinones I, Sellergren B, Guiochon G, J. Chromatogr. A, 927, 1 (2001)
Ye L, Cormack PAG, Mosbach K, Anal. Chim. Acta, 435, 187 (2001)
Kempe M, Anal. Chim. Acta, 68, 1948 (1996)
Fischer LMR, Ekberg B, Mosbach K, J. Am. Chem. Soc., 113, 9358 (1991)
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Ramstrom O, Yu C, Mosbach K, J. Mol. Recognit., 9(5-6), 691 (1996)
Kempe M, Mosbach K, J. Chromatogr. A, 664, 276 (1994)
Schweitz L, Andersson LI, Nilsson S, J. Chromatogr. A, 792, 401 (1997)
Ramstrom O, Nicholls IA, Mosbach K, Tetrahedron: Asymmetry, 5(4), 649 (1994)
Kempe M, Mosbach K, J. Chromatogr. A, 691, 317 (1995)
Xu XJ, Zhu LL, Chen LR, J. Chromatogr. B, 804, 61 (2004)
Ellwanger A, Berggren C, Bayoudh S, Crecenzi C, Karlsson L, Owens PK, Ensing K, Cormack P, Sherringtonc D, Sellergren B, Analyst, 126, 784 (2001)
Plunkett SD, Arnold FH, J. Chromatogr. A, 708, 19 (1995)
Fairhurst RE, Chassaing C, Venn RF, Mayes AG, Biosens. Bioelectron., 20, 1098 (2004)
Sellergren B, J. Chromatogr. A, 673, 133 (1994)
