Articles & Issues

Language: korean

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received April 11, 2008
Accepted May 9, 2008

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All issues

정상상태의 4 구역 SMB 공정에 유입된 이성분계 물질의 체류 분석

Retention Analysis of Binary Mixture Injected into a Four-Zone Simulated Moving Bed at Steady-State

양진효 김진일 구윤모^†

Jinhyo Yang Jin-Il Kim Yoon-Mo Koo^†

인하대학교 생물공학과 초정밀생물분리기술연구센터, 402-751 인천시 남구 용현동 253

Department of Biological Engineering, Inha University, ERC for Advanced Bioseparation Technology, Inha University, 253, Yonghyun-dong, Nam-gu, Incheon 402-751, Korea

Korean Chemical Engineering Research, August 2008, 46(4), 732-738(7), NONE Epub 10 September 2008

Download PDF

Abstract

SMB 공정은 석유화학, 정밀화학, 제약 제품들을 연속대량으로 정제할 수 있는 크로마토그래피 기술로서 관련 산업에서 많은 관심을 얻고 있다. 최근 생명공학 기술의 발달과 함께, 다양한 생물 유래의 유용물질에 대한 SMB 공정의 적용이 시도되어 보고되고 있다. 또한, 다양한 방법으로 SMB 공정의 분리 메커니즘을 이해하는 연구들이 보고 되었다. 이와 같은 연구에서는 목적산물을 생산하는 일련의 생산과정에서 SMB 공정의 조업을 보다 용이하게 하고, SMB 공정에서 발생할 수 있는 문제의 원인을 분석하고 있다. 이번 연구에서는 정상상태에 이른 SMB 공정에서 기주입된 시료(psicose (A) 및 fructose (B) 혼합물)와 새로이 주입되는 시료(psicose (C) 및 fructose (D) 혼합물)의 체류 특성을 알아보는 모사실험을 수행하였다. 새로운 원료의 주입시점이 하나의 교환시간 중 앞부분일수록 기주입된 물질은 보다 빠르게 SMB 공정에서 유출되는 것을 확인할 수 있었다. 마찬가지로, 새로이 주입되는 물질들도 이와 마찬가지로 교환시간의 전반부에 주입될수록 보다 빨리 정상상태에 도달하는 것을 확인하였다.

Simulated moving bed (SMB) process is a continuous chromatographic technology used to separate a large amount of petrochemicals, fine chemicals, pharmaceuticals, and so on, drawing a great attraction of related industries. With the recent development of biotechnology, the SMB process has been adopted for the separation of various useful bio-products. Attempts to understand the separation mechanism of the SMB process in many aspects are reported in many publications. These researches have dealt with the improvement of SMB for easier operation and solving problem in process. The feed mixture fed into the SMB process may be of different concentration batch by batch rather than in uniform concentration. Retention behaviors of feed (psicose (A) and fructose (B) mixture) existing in the SMB unit in dynamic steady-state and feed (psicose (C) and fructose (D) mixture) newly injected into the SMB were analyzed. It was observed that the existing components, (A) and (B), were eluted relatively faster as the injection time of new feed was earlier during the port-switching period. In addition, the components (C) and (D) were eluted earlier as fresh feed was injected earlier in a port-switching time.

Keywords

Simulated Moving Bed SMB Retention Analysis Residence Analysis

References

Oh NS, Lee CH, Koo YM, Korean Chem. Eng. Res., 43(6), 715 (2005)
Broughton DB, Chem. Eng. Prog., 64(1), 60 (1968)
Storti G, Mazzotti M, Morbidelli M, Carra S, AIChE J., 39(3), 471 (1993)
Minceva M, Pais LS, Rodrigues AE, Chem. Eng. Process., 42(2), 93 (2003)
Migliorini C, Mazzotti M, Morbidelli M, J. Chromatogr. A, 827(2), 191 (1998)
Hashimoto K, Adachi S, Shirai Y, Agric. Biol. Chem., 52(11), 2161 (1998)
Ma Z, Wang NHL, J. Chromatogr. A, 805(1), 37 (1998)
Oh NS, Lee CH, Kim JI, Koo YM, Ind. Eng. Chem. Res., 43(3), 360 (2005)
Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A, 769(1), 3 (1997)
Han SK, Yeo MS, Lee JK, Park TJ, Koo YM, Row KH, HWAHAK KONGHAK, 41(6), 728 (2003)
Lee HH, Kim KM, Lee CH, KIC News, 10(6), 23 (2007)
Blent J, Nicoud RM, Analusis Magazine, 26(7), 60 (1998)
Mun SY, News Inf. Chem. Eng., 23(2), 159 (2005)
Mun SY, Xie Y, Wang NHL, AIChE J., 49(8), 2039 (2003)
Migliorini C, Mazzotti M, Morbidelli M, J. Chromatogr. A, 827(2), 161 (1998)
Chung SF, Wen CY, AIChE J., 14, 857 (1968)