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Received April 16, 2010
Accepted June 14, 2010
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액적 기반의 미세유체 시스템의 현황
Droplet Based Microfluidic System
충남대학교 화학공학과, 305-764 대전시 유성구 궁동 220
Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Korea
rhadum@cnu.ac.kr
Korean Chemical Engineering Research, October 2010, 48(5), 545-555(11), NONE Epub 17 November 2010
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Abstract
최근 액적 기반의 미세유체 시스템은 물리, 화학, 생물학등의 기초과학과 재료과학 분야까지 매우 폭넓게 활용되고 각광받고 있는 기술분야이다. 본 총설은 액적기반 미세유체 시스템의 미세유체 반응기 제작 기술, 액적 형성 원리, 액적 혼합 및 제어, 그리고 새로운 기능성 재료의 합성등의 폭넓은 응용분야에 관해 자세하게 소개하고자 한다. 더불어 액적기반 미세유체 시스템의 가장 큰 장점인 입자의 크기 조절 방법, 형태, 모양 및 구조의 제어 기술에 관해 논의하고자 한다.
Recently, droplet-based microfluidic systems are widely used in various areas ranging from fundamental science including chemistry, biology, and physics to material science and engineering. This article reviews recent development in the droplet based microfluidic system from basic fabrication of tiny device, principle of droplet formation, merging, mixing, control of droplets, and application for the synthesis of novel functional materials. We discuss strong_x000D_
advantages of the droplet based microfluidics in point of control of particle size, morphologies, shapes, and structures.
Keywords
References
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Kamholz AE, Lab on a Chip, 4, 16 (2004)
Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR, Weigl BH, Nature, 442, 412 (2006)
deMello AJ, Nature, 442, 394 (2006)
El-Ali J, Sorger PK, Jensen KF, Nature, 442, 403 (2006)
Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR, Science, 310, 1793 (2005)
Lucchetta EM, Munson MS, Ismagilov RF, Lab on a Chip, 6, 185 (2006)
Jeon NL, Baskaran H, Dertinger SKW, Whitesides GM, Water LVD, Toner M, Nature Biotechnology, 20, 826 (2002)
Squires TM, Quake SR, Reviews of Modern Physics, 77, 977 (2005)
Kobayashi I, Uemura K, Nakajima M, Colloids Surf. A: Physicochem Eng. Asp., 296, 285 (2007)
Fair R, Microfluidics and Nanofluidics, 3, 245 (2007)
Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA, Science, 308, 537 (2005)
Pollack MG, Shenderov AD, Fair RB, Lab on a Chip, 2, 96 (2002)
Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE, Annu Rev. Biomed. Eng., 3, 335 (2001)
Ziaie B, Baldi A, Lei M, Gu Y, Siegel RA, Adv. Drug Delivery Rev., 56, 145 (2004)
Xia Y, Whitesides GM, Annu. Rev. Mater. Sci., 28, 153 (1998)
Kim BY, Hong LY, Chung YM, Kim DP, Lee CS, Adv. Funct. Mater., 19(23), 3796 (2009)
Ganguli D, Ganguli M, Inorganic particle synthesis via macroand microemulsions, Kluwer Academic/Plenum Publishers, New York (2003)
Nisisako T, Torii T, Takahashi T, Takizawa Y, Adv. Mater., 18(9), 1152 (2006)
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Hettiarachchi K, Talu E, Longo ML, Dayton PA, Lee AP, Lab on a Chip, 7, 463 (2007)
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Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM, Lab on a Chip, 6, 437 (2006)
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Nie ZH, Li W, Seo M, Xu SQ, Kumacheva E, J. Am. Chem. Soc., 128(29), 9408 (2006)
Jeong W, Kim J, Kim S, Lee S, Lab on a Chip, 4, 576 (2004)
Jung JH, Choi CH, Chung S, Chung YM, Lee CS, Lab on a Chip, 9, 2596 (2009)
Poenar DP, Iliescub C, Carp M, Pang AJ, Leck KJ, Sensors and Actuators A, 139, 162 (2007)
Chandrasekaran A, Acharya A, You JL, Soo KY, Packirisamy M, Stiharu I, Darveau A, Sensors, 1901 (2007)
Huang KS, Liu MK, Wu CH, Yen YT, Lin YC, J. Micromech. Microeng., 17, 1428 (2007)
