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Received December 23, 2010
Accepted January 11, 2011
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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록소프로펜 라세미체 분리를 위한 유사이동층 크로마토그래피의 전산모사
Simulated Moving Bed(SMB) Chromatography Simulation for Loxoprofen Racemates Separation
충남대학교 화학공학과, 305-764 대전시 유성구 궁동 220
Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Korea
ihkim@cnu.ac.kr
Korean Chemical Engineering Research, October 2011, 49(5), 623-627(5), NONE Epub 30 September 2011
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Abstract
Loxoprofen racemate를 분리하기 위해 SMB에서 운전조건을 탐색하였다. Aspen simulator를 이용하여 전산모사를 함으로써 loxoprofen racemate를 분리할 수 있는 운전조건을 다음과 같이 제시할 수 있었다. Raffinate 순도를 증가시키기 위해 삼각도에서 왼쪽 중간 부분의 m2, m3 좌표를 정하여야 하며 내부농도 분포도에서 raffinate와 extract 분포곡선을 겹치지 않도록 하여야 한다.
Simulated moving bed(SMB) chromatography was simulated for separating loxoprofen racemates. Aspen chromatography simulator was utilized with Henry’s constants of loxoprofen racemates which were obtained by batch chromatography experiments. Raffinate stream concentrations as well as purities were calculated with various m2 and m3 values in the triangle diagram obtained from two Henry’s constants 7.9 and 10.1. Purity values are high under the_x000D_
conditions that the m2-m3 coordinates are near the left central region in the diagram and feed flow rates are lower. Concentration profiles of raffinate and extract streams along SMB columns explain the purity change in the case of increasing the column numbers installed at SMB.
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