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Language: korean

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received January 2, 2012
Accepted February 13, 2012

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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후코이단의 분자량이 화장품기능성에 미치는 영향

The Effect of Fcoidan Molecula Weight on Cosmetic Function

차성한 안명원 이정식¹ 김영숙¹ 김동욱² 변태강³ 박권필^†

Seong Han Cha Myeong Won Ahn Jung Shik Lee¹ Young Suk Kim¹ Dong-uk Kim² Tae Gang Byun³ Kwon pil Park^†

순천대학교 화학공학과, 540-742 전남 순천시 매곡동 315 ¹(주)해림후코이단, 537-801 전남 완도군 완도읍 가용리 1088-8 ²인제대학교 제약공학과, 621-749 경남 김해시 어방동 607 ³건양대학교 식품생명공학과, 320-711 충남 논산시 내동 26

Department of Chemical Engineering, Sunchon National University, 315 Maegok-dong, Suncheon-si, Jeonnam 540-742, Korea ¹Haerim Fucoidan Ltd, 1088-8 Gayong-ri Wando-eup, Wando-gun, Jeonnam 537-801, Korea ²Department of Pharmaceutical Engineering, Inje University, 607 Obang-dong, Gimhae-si, Gyongnam 621-749, Korea ³Department of Food Science and Biotechnology, Konyang University, 26 Nae-dong, Nonsan-si, Chungnam 320-711, Korea

parkkp@sunchon.ac.kr

Korean Chemical Engineering Research, August 2012, 50(4), 604-609(6), NONE Epub 25 July 2012

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Abstract

기능성화장품 소재로 사용하기 위한 후코이단의 특성 및 후코이단 분자량의 영향에 대해 연구하였다. 후코이단은 미역 포자엽에서 추출하였고 접촉글로우방전 전기분해(CGDE)방법에 의해 후코이단 분자량(35~160 kDa)을 조절하였다. 후코이단의 tyrosinase inhibition, 보습력, elastase 활성저해 효과와 항산화력(DPPH assay, radical scavenging)을 측정하여 화장품으로서 가능성을 확인하였다. 후코이단의 보습력은 최고의 보습제 중의 하나인 히아루론산의 보습력보다 높았고, 분자량이 감소함에 따라 보습력이 약간 증가하였다. 주름개선 효과실험인 elastase 활성저해 효과 실험결과 표준 비교물질인 adenosine 보다 높은 elastase 활성저해 효과를 보였다. 최고의 tyrosinase 저해효과, elastase 활성저해 효과, 항산화력(DPPH assay, radical scavenging)을 갖는 후코이단의 분자량은 100 kDa이었다.

Properties of fucoidan used for functional cosmetic ingredients and the effect of fucoidan molecular weight on the cosmetic functions were studied. Fucoidan was extracted from Undaria pinnatifida sporophylls and molecular weight (35~160 kDa) of fucoidan was controlled by contact glow discharge electrolysis (CGDE). To test possibility of fucoidan as a cosmetics material, tyrosinase inhibition property, water-holding property, elastase activity inhibition property and DPPH free radical scavenging property were measured. Water-holding property of fucoidan was higher than that of hyaruronic acid, which is known as the one of the best water-holding material. The water-holding strength of fucoidan slightly increase as molecular weight of fucoidan decrease. Elastase activity inhibition (anti wrinkle effect) of fucoidan was higher than that of adenosine using standard material for anti wrinkle test. Optimum molecular weight of fucoidan to obtain highest tyrosin inhibition effect, elastase inhibition effect and radical scavenger effect is 100 kDa.

Keywords

Fucoidan Cosmetic Ingredient Molecular Weight Water-holding Anti-wrinkle Elastase

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