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Received February 7, 2012
Accepted March 11, 2012
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미세채널에서 수력학적 조절을 통한 단분산성 다중 액적 생성
Microfluidic Preparation of Monodisperse Multiple Emulsion using Hydrodynamic Control
충남대학교 화학공학과, 305-764 대전 유성구 궁동 220
Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-Gu, Daejeon 305-764, Korea
rhadum@cnu.ac.kr
Korean Chemical Engineering Research, August 2012, 50(4), 733-737(5), NONE Epub 25 July 2012
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Abstract
본 연구는 미세유체의 수력학적 조절을 통한 단분산성 다중 액적 형성방법을 기술한다. 다중 액적을 형성하기 위해 별도의 표면 개질이 필요 없는 co-flowing stream 시스템과 유리 모세관을 이용하여 미세유체 칩을 제작하였다. 유리모세관 미세유체 칩 내부로 0.5 wt% Tween 20이 함유된 증류수, n-hexadecane (5 wt% Span 80), 그리고 10 wt% poly(vinyl alcohol) (PVA) 수용액을 흘려줌으로써 단분산성 다중 액적(W/O/W)을 성공적으로 형성하였다. 더불어, 내부 액적의 개수를 제어하기 위해 수력학적 변수로 작용하는 중간 유체와 최외각 유체의 부피유속을 고정시키고 내부 유체의 부피유속을 조절하는 방법을 사용하여 다양한 내부 액적을 지니는 다중 유화 액적을 성공적으로 완성하였다. 이와 같은 미세유체 시스템을 통해 형성된 다중 액적은 내부물질의 종류에 따라 다양한 화학반응을 위한 하나의 독립된 마이크로 반응기로 사용될 수 있을 것으로 기대한다.
This study reports the microfluidic preparation of monodisperse multiple emulsions using hydrodynamic control. To generate multiple emulsions, we fabricate a microfluidic capillary device based on co-flowing stream without any surface modification of microchannels. Based on the system, we can successfully generate multiple emulsions (W/O/W) using water containing 0.5 wt% Tween 20, n-hexadecane with 5 wt% Span 80, and 10 wt% poly (vinyl alcohol)(PVA) aqueous solution, respectively. Furthermore, we control the number of inner droplets by modulation of flow rate of inner fluid at fixed flow rate of middle and outer fluid. The multiple emulsions having precisely controlled inner droplets’ size and number can be applicable for multiple chemical reactions as an isolated microreactor.
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Matsumoto S, Kita Y, Yonezawa D, J. Colloid Interface Sci., 57, 353 (1976)
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Choi CH, Jung JH, Hwang TS, Lee CS, Macromol. Res., 17(3), 163 (2009)
Choi CH, Jung JH, Yoon TH, Kim DP, Lee CS, J. Chem. Eng. Jpn., 41(7), 649 (2008)
Whitesides GM, Nature., 442(7101), 368 (2006)
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Duffy DC, McDonald JC, Schueller OJA, Whitesides GM, Anal Chem., 70(23), 4974 (1998)
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