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Received April 3, 2012
Accepted May 10, 2012
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1,3-프로판디올의 생물학적 생산을 위한 분리공정
Separation Processes of Biologically Produced 1,3-Propanediol
한국교통대학교 화공생물공학과, 380-702 충북 충주시 대학로 50
Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju-si, Chungbuk 380-702, Korea
hongyk@ut.ac.kr
Korean Chemical Engineering Research, October 2012, 50(5), 759-765(7), 10.9713/kcer.2012.50.5.759 Epub 2 October 2012
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Abstract
바이오 디젤 생산량 증가에 따라 공정 중에 부산물로 발생하는 글리세린의 과잉공급 및 가격 하락이 이루어지고 있다. 이에 따라 글리세린에 기반한 다양한 화학제품생산과 관련된 연구가 활발히 진행되고 있으며 글리세린을 탄소원으로 한 1,3-프로판디올의 생물학적 생산은 그 중 하나이다. 1,3-프로판디올은 지금까지 화학적인 방법을 통해 생산되어 왔으나 생물학적인 방법을 통해 생산될 경우 공정의 친환경성 및 경제성 확보와 더불어 1,3-프로판디올을 중합원료로 하는 PTT (Poly (trimethylene terephthalate))의 바이오폴리머로서의 활용을 가능하게 한다. 그럼에도 글리세린 유래1,3-프로판디올의 생물학적 생산의 경제성에 있어 핵심은 경제적인 분리공정의 수립에 있다. 본 총설에서는 1,3-프로판_x000D_
디올을 분리하기 위한 공정들에 대한 연구 동향을 소개하고 최근 에너지 절감과 더불어 1,3-프로판디올 분리와 부산물 제거를 동시에 달성할 있는 공정으로 주목받고 있는 수상이성분계 추출에 대한 연구개발 동향 및 전망을 제시하고자 한다.
As the biodiesel production is increasing rapidly, the crude glycerol, which is principal by-product of biodiesel production, has also been generated in a large amount. Many research studies on value-added utilization of glycerol are under investigation. 1,3-Propandiol is a promising chemical which can be produced from fermentation of glycerol because the application of 1,3-propanediol is mainly in the production of bio-PTT (Poly(trimethylene terephthalate). However, the cost of downstream processes in the biological production of 1,3-propanediol can make a high portion in the total production cost. This review summarizes the present state of separation processes in each step studied for the removal of impurities and the recovery of 1,3-propanediol from its fermentation broth. Furthermore, ATPE (Aqueous Two Phases Extraction) process is suggested as an attractive alternative for the primary separation process of 1,3-propanediol because ATPE is convenient for the simultaneous removal of microbial cells and impurities such as salts of organic acids and the separation of 1,3-propanediol from fermentation broth.
Keywords
References
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Willke T, Vorlop K, Eur. J. Lipid Sci. Technol., 110, 831 (2008)
Zeng AP, Biebl H, Adv. Biochem. Eng. Biotechnol., 74, 239 (2002)
Raynaud C, Sarcabal P, Meynial-Salles I, Croux C, Proc. Natl. Acad. Sci. USA., 100, 5010 (2003)
Homann T, Tag C, Biebl H, Deckwer W, Appl. Microbiol. Biotechnol., 33, 121 (1990)
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Otte B, Grunwaldt E, Mahmoud O, Jennewein S, Appl. Environ. Microbiol., 75, 7610 (2009)
Chen Z, Liu HJ, Liu DH, Enzyme Microb. Technol., 45(4), 305 (2009)
Zhu JG, Li S, Ji XJ, Huang H, World J. Microbiol. Biotechnol., 25, 1217 (2009)
Yang G, Tian JS, Li JL, Appl. Microbiol. Biotechnol., 73(5), 1017 (2007)
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Deckwer WD, Fems Microbiol. Rev., 16, 143 (1995)
Hermann BG, Patel M, Appl. Biochem. Biotechnol., 136(3), 361 (2007)
Lee EG, Moon SH, Chang YK, Yoo IK, Chang HN, J. Membr. Sci., 145(1), 53 (1998)
Kim YH, Moon SH, J. Chem. Technol. Biotechnol., 76(2), 169 (2001)
Kurzrock T, Weuster-Botz D, Biotechnol. Lett., 32(3), 331 (2010)
Wu RC, Xu YZ, Song YQ, Luo JA, Liu D, Sep.Purif. Technol., 83, 9 (2011)
Grothe E, “Konzeption und Wirtschaftlichkeit der Industriellen Glycerinvergarung zu 1,3-Propanediol,” Ph.D. Dissertation, VDI Verlag GmbH, Dusseldorf (2000)
Roturier JM, Fouache C, Berghmans E, “Process for the Purification of 1,3-Propanediol from a Fermentation Medium,” U.S. Patent No. 6,428,992 (2002)
Hilaly AK, Binder TP, “Method of Recovering 1,3-Propanediol from Fermentation Broth,” U.S. Patent No. 6,479,716 (2002)
Cho MH, Joen SI, Pyo SH, Mun S, Kim JH, Proc. Biochem., 41, 739 (2006)
Xiu ZL, Zeng AP, Appl. Microbiol. Biotechnol., 78(6), 917 (2008)
Malinowski JJ, Biotechnol. Prog., 16(1), 76 (2000)
Hao J, Liu HJ, Liu DH, Ind. Eng. Chem. Res., 44(12), 4380 (2005)
Hao J, Xu F, Liu HJ, Liu DH, J. Chem. Technol. Biotechnol., 81(1), 102 (2006)
Hong YK, Hong WH, Sep. Purif. Technol., 42(2), 151 (2005)
Han DH, Hong YK, Hong WH, Korean J. Chem. Eng., 17(5), 528 (2000)
Hong YK, Adv. Mater.Res., 320, 191 (2011)
Greve A, Kula MR, Bioproc. Biosyst. Eng., 6, 173 (1990)
Li ZG, Jiang B, Zhang DJ, Xiu ZL, Sep. Purif. Technol., 66(3), 472 (2009)
Li Z, Teng H, Xiu Z, Proc. Biochem., 46, 586 (2011)
Aydogan O, Bayraktar E, Mehmetoglu U, Kaeding T, Zeng AP, Eng. Life. Sci., 10, 121 (2010)
