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Language: korean

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received May 22, 2013
Accepted July 2, 2013

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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황벽나무, 두충나무 등을 포함하는 복합수목추출물의 항균활성 및 안전성 시험

Antimicrobial Activity and Safety Test of Mixed Plant Extracts Including Phellodendron Amurense and Eucommia Ulmides Oliv.

김현우 신혜진 황단비 이지은 박만춘 김진홍¹ 김동욱^†

Hyunwoo Kim Hyejin Shin Danbi Hwang Jieun Lee Manchun Bak Jinhong Kim¹ Donguk Kim^†

인제대학교 제약공학과, 621-749 경남 김해시 어방동 607 ¹바이오메틱스, 621-749 경남 김해시 어방동 인제대학교 성산관 F-1006

Department of Pharmaceutical Engineering, Inje University, 607 eobang-dong, Gimhae-si, Gyongnam 621-749, Korea ¹Biometics, F-10, Sungsan-building, Inje University, eobang-dong, Gimhae-si, Gyongnam 621-749, Korea

pedkim@inje.ac.kr

Korean Chemical Engineering Research, October 2013, 51(5), 536-539(4), 10.9713/kcer.2013.51.5.536 Epub 1 October 2013

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Abstract

본 연구에서는 황벽나무, 두충나무 등을 포함하는 복합수목추출물의 항균활성 효과 및 안전성에 대해 검토하였다. 항균활성은 피부상재균이며 기회 병원성균인 Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli 및 Candida albicans에 대해 disc 확산법으로 실험되었다. 안전성 시험으로는 단회 경구투여 독성시험, 단회투여 흡입독성 시험, 반복투여 흡입독성시험이 실시되었다. 항균력효과시험 결과 추출물은 Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans에 대해 우수한 항균활성을 보여주었으나, Escherichia coli에서는 항균활성이 없었다. 복합수목추출물의 단회 경구투여 독성시험, 단회투여 흡입독성시험 및 반복투여 흡입독성시험의 결과 독성은 관찰되지_x000D_ 않았다. 따라서 황벽나무, 두충나무 등을 포함한 복합수목추출물은 천연 항살균제로서 상업화 가능성이 매우 높음을 알 수 있었다.

In this study, mixed plant extracts including Phellodendro namurense and Eucommia ulmides Oliv were tested for antimicrobial activity and safety. Antimicrobial activity was measured by disc diffusion method using normal skin flora and opportunistic microbes such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. As safety test, single dose oral toxicity test, single dose inhalation toxicity test and repeat dose inhalation toxicity test were done. From antimicrobial test, plant extracts showed significant antimicrobial activity Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, however, did not indicate any antibacterial effect on Escherichia coli. From 3 kinds of safety tests, toxicity of mixed plant extracts was not observed. From experimental results, mixed plant extracts including Phellodendro namurense and Eucommia ulmides Oliv showed good potential for natural antimicrobial agent.

Keywords

Phellodendro Namurense Eucommia Ulmides Oliv. Antimicrobial Activity Safety

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