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Received September 17, 2013
Accepted October 11, 2013
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미세유체의 효율적인 액적 합류를 위한 정체현상 조절
Stagnation of Droplet for Efficient Merging in Microfluidic System
충남대학교 화학공학과, 305-764 대전광역시 유성구 궁동 220
Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-Gu, Daejeon 305-764, Korea
rhadum@cnu.ac.kr
Korean Chemical Engineering Research, February 2014, 52(1), 106-112(7), 10.9713/kcer.2014.52.1.106 Epub 3 February 2014
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Abstract
본 연구에서는 미세액적을 효과적으로 합류시키기 위하여 미세기둥 구조들에 따른 영향 및 정체 현상 조절에 관한 연구를 수행하였다. 최적의 미세액적 합류조건을 찾기 위하여 매우 정교하게 조절이 가능한 미세 밸브를 접목하였다. 수용성 미세액적은 연속상으로 0.5 wt% Span 80이 함유된 미네랄 오일을 사용하였다. 합류과정은 미세유체 칩 내부에 위치한 미세기둥의 구조와 배치를 통해 액적 주위의 압력과 액적 내부의 라플라스 압력의 차이를 조정하여 수행된다. 마지막으로 최적의 합류 구조를 지닌 미세유체시스템에서 효소 생화학반응 실험을 수행함으로써 본 장치가 생물학 및 생화학 실험을 수행하는 유용한 도구로서 사용될 수 있음을 입증하였다.
Here, we demonstrated the optimum design of pillar microstructure for efficient microdroplet merging. The microfluidic device mainly consisted of programmable microvalves and pillar microstructures. Based on the system, aqueous droplets were continuously generated at T-junction using actuating of integrated programmable microvalaves under the immiscible continuous fluid (mineral oil containing 0.5 wt% Span 80). The principle of merging process_x000D_
depended on the competitive correlation of hydraulic pressure of continuous phase and Laplace pressure of the droplet. We found that the design of the micropillars controls above two pressures. Finally, it was demonstrated that the microfluidic system could be able to efficient biochemical reaction. We expect that the microfluidic system is useful analytical or reaction tools in fundamental science, biotechnology, and chemical engineering.
Keywords
References
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Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA, Science, 308(5721), 537 (2005)
Choi CH, Weitz DA, Lee CS, Adv. Mater., 25(18), 2536 (2013)
Kang SM, Choi CH, Hwang S, Jung JM, Lee CS, Korean Chem. Eng. Res., 50(4), 733 (2012)
Churski K, Kaminski TS, Jakiela S, Kamysz W, Baranska- Rybak W, Weibel DB, Garstecki P, Lab Chip, 12(9), 1629 (2012)
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Fidalgo LM, Abell C, Huck WTS, Lab Chip, 7(8), 984 (2007)
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Guo F, Liu K, Ji XH, Ding HJ, Zhang M, Zeng QA, Liu W, Guo SS, Zhao XZ, Appl. Phys. Lett., 97, 233701 (2010)
Unger MA, Chou HP, Thorsen T, Scherer A, Quake SR, Science, 288(5463), 113 (2000)
Zeng SJ, Li BW, Su XO, Qin JH, Lin BC, Lab Chip, 9(10), 1340 (2009)
