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Received August 27, 2013
Accepted September 25, 2013
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액적 기반의 미세유체 시스템을 이용한 초고속 대용량 스크리닝
Droplet-based Microfluidic Device for High-throughput Screening
충남대학교 화학공학과, 305-764 대전광역시 유성구 궁동 220
Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Korea
rhadum@cnu.ac.kr
Korean Chemical Engineering Research, April 2014, 52(2), 141-153(13), 10.9713/kcer.2014.52.2.141 Epub 1 April 2014
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Abstract
액적기반의 미세유체 시스템은 마이크로 시험관으로서 화학, 생물학 연구에 적용하기 위해 개발되었다. 미세유체 시스템에서 피코부피(picoliter)의 매우 작은 액적은 소형화된 시스템 내에서 잘 정형화 되고 구획화된 반응기로 제공되어 진다. 매우 작은 액적에서의 반응은 자동화된 초고속 대용량 스크리닝 시스템을 통하여 저가이면서 고효율적으로 수행될 수 있다. 본 총설에서는 액적 기반의 미세유체시스템의 기능들인 액적 형성, 정교한 액적 제어, 다양한 응용분야에 대해 소개하고자 한다. 또한 화학적, 생물학적 새로운 응용분야에 관해 알아보고, 기존의 방법과 비교하여 액적기반의 미세유체 시스템이 갖는 장점에 관해 논의하고자 한다.
Droplet based microfluidic systems have been developed for the application of biological and chemical research field. A picoliter droplet in microfluidic device provides a compartmentalized and well-defined reactor in miniaturized system. The microfluidic system with small droplets can reduce reagent cost and enhance efficiency through automated high-throughput screening system. In this review, we summarize the functionality of droplet based microfluidic system including droplet generation, precise droplet control, and various applications. In addition, this article reviews current applications in chemistry and biology, and discuss advantages of droplet based microfluidics compared with conventional manner.
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Kemna EWM, Schoeman RM, Wolbers F, Vermes I, Weitz DA, van den Berg A, Lab Chip, 12(16), 2881 (2012)
Koster S, Angile FE, Duan H, Agresti JJ, Wintner A, Schmitz C, Rowat AC, Merten CA, Pisignano D, Griffiths AD, Weitz DA, Lab Chip, 8(7), 1110 (2008)
El Debs B, Utharala R, Balyasnikova IV, Griffiths AD, Merten CA, Proc. Natl. Acad. Sci. USA, 109(29), 11570 (2012)
