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Received March 29, 2016
Accepted August 17, 2016
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Formatotrophic Production of Poly-β-hydroxybutyric Acid (PHB) from Methylobacterium sp. using Formate as the Sole Carbon and Energy Source
Department of Chemical Engineering, Kwangwoon University, 53, Gwangun-ro 6-gil, Nowon-gu, Seoul, 01899, Korea
metalkim@kw.ac.kr
Korean Chemical Engineering Research, October 2016, 54(5), 719-721(3), 10.9713/kcer.2016.54.5.719 Epub 6 October 2016
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Abstract
Formate has been considered as an environmentally sustainable feedstock that can be used to accelerate the production of valuable chemicals. This study presents brief results of the formatotrophic production of poly-β-hydroxybutyric acid (PHB) by Methylobacterium sp. To evaluate the production of PHB, five species of Methylobacteria were tested using formate as the sole carbon and energy source. Methylobacterium chloromethanicum CM4 exhibited the highest productivity of PHB, which showed 1.72 g/L PHB production, 32.4% PHB content, and 0.027 g-PHB/g-formate PHB yield. These results could be used for the formatotrophic production of PHB with the concurrent reduction of CO2 to formate.
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References
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Goldberg I, Rock JS, Ben-Bassat A, Mateles RI, Biotechnol. Bioeng., 18, 1657 (1976)
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Braunegg G, Sonnleitner B, Lafferty RM, Eur. J. Appl. Microbio. Biotechnol., 6, 29 (1978)
Bourque D, Pomerleau Y, Groleau D, Appl. Microbiol. Biotechnol., 44(3-4), 367 (1995)
Kim SW, Kim P, Lee HS, Kim JH, Biotechnol. Lett., 18(1), 25 (1996)
Yamane T, Biotechnol. Bioeng., 41, 165 (1993)
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Chistoserdova L, Crowther GJ, Vorholt JA, Skovran E, Portais JC, Lidstrom ME, J. Bacteriol., 189, 9076 (2007)
