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Received April 11, 2017
Accepted August 9, 2017
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원료의약품 분진의 폭발 위험성 평가
Explosion Hazard Assessment of Pharmaceutical Raw Materials Powders
한국산업안전보건공단 산업안전보건연구원, 34122 대전광역시 유성구 엑스포로 339번길 30
Occupational Safety & Health Research Institute, KOSHA, 30, Expo-ro 339beon-gil, Yuseong-gu, Daejeon, 34122, Korea
leekw@kosha.or.kr
Korean Chemical Engineering Research, October 2017, 55(5), 600-608(9), 10.9713/kcer.2017.55.5.600 Epub 19 October 2017
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Abstract
산업현장에서 취급되거나 가공되는 원료의약품 분진의 폭발 위험성은 항상 존재하며, 이로 인한 폭발사고가 자주 발생되고 있다. 본 연구에서는 원료의약품 시료 3종의 분진폭발특성을 측정하였다. 주요 폭발특성 측정값은 록소프로펜산은 평균 입경이 5.31 μm이며, Pmax는 8.4 bar, 최소점화에너지는 1 mJ
Hazard risk of explosion on pharmaceutical raw materials dust in pharmaceutical industry often exists when it is handled or processed in the industrial sites, and explosion accident is caused by this. In this study, the dust explosion characteristics of the three pharmaceutical raw materials samples were measured. The main explosion characteristics are as follows: Pmax, MIE and MIT of loxoprofen acid having 5.31 °C of median diameter are obtained 8.4 bar, 1 mJ
Keywords
References
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Chungcheong Regional Center for Chemical Accident Prevention, “Report of Accident Insvestigation,” KOSHA(2016).
Han OS, Han IS, KIGAS, 18(4), 21 (2014)
Han OS, Choi YR, Han IS, Lee JS, Korean Chem. Eng. Res., 48(5), 603 (2010)
EN 14034-1, Determination of explosion characteristics of dust clouds-Part 1:Determination of the maximum explosion pressure Pmax of dust clouds, European Standard(2011).
EN 14034-2, Determination of explosion characteristics of dust clouds-Part 1:Determination of the maximum rate of explosion pressure rise(dp/dt)max of dust clouds, European Standard(2011).
EN 14034-3, Determination of explosion characteristics of dust clouds-Part 1:Determination of the lower explosion limit LEL of dust clouds, European Standard(2011).
EN 13821, Potentially explosive atmospheres-explosion prevention and protection-Determination of minimum ignition energy of dust/air mixtures, European Standard(2002).
KS C IEC 61241-2-1, Electrical apparatus for use in the presence of combustible dust-Test method for determination the minimum ignition temperature of dust, Korean Industrial Standard(2003).
Han OS, Lee SH, KIGAS, 16(5), 7 (2012)
Han OS, Lee KW, Korean Chem. Eng. Res., 54(3), 367 (2016)
Eckhoff RK, Dust explosion in the process industries (3rd ed.), Amsterdam: Gulf Professional Publishing(2003).
NFPA 77, Recommended Practice on Static Electricity, National Fire Protection Association(2014).
ASTM E 1515-14, Standard Test Method for Minimum Explosible Concentration of Combustible Dusts(2014).
ASTM E 1491-06, Standard Test Method for Minimum Autoignition Temperature of Dust Clouds(2006).
Abbasi T, Abbasi SA, J. Hazard. Mater., 140(1-2), 7 (2007)
OSHA, “Hazard Communication Guidance for Combustible Dusts,” OSHA 3371-08(2009).
Abuswer M, Amyotte P, Khan F, Morrison L, J. Loss Prev. Process Ind., 26(6), 1530 (2013)
Ebadat V, J. Loss Prev. Process Ind., 23(6), 907 (2010)
Field, Peter, Handbook of powder technology volume 4: dust explosions, Amsterdam: Elsevier(1982).
NFPA 499, National Fire Protection Association(2013).
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