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Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received February 28, 2018
Accepted April 3, 2018

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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괭이밥과 추출물의 기능성화장품 소재로서의 특성

Functional Cosmetic Characteristics of the Oxalidaceae Extracts

한동균 노대영 심하은 정선하 박석호 최희선¹ 김동욱^†

Donggyun Han Daeyoung Noh Haeun Shim Sunha Jeong Sukho Park Heesun Choi¹ Donguk Kim^†

인제대학교 제약공학과, 50834 경상남도 김해시 인제로 197 ¹동아대학교 식품영양학과, 49315 부산광역시 사하구 낙동대로 550번길 37

Department of Pharmaceutical Engineering, Inje University, 197, Inje-ro, Gimhae-si, Gyeongsangnam-do, 50834, Korea ¹Department of Food Science and Nutrition, Dong-A University, 37, Nakdong-daero 550beon-gil, Saha-gu, Busan, 49315, Korea

pedkim@inje.ac.kr

Korean Chemical Engineering Research, June 2018, 56(3), 309-314(6), 10.9713/kcer.2018.56.3.309 Epub 4 June 2018

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Abstract

본 연구에서는 괭이밥, 큰괭이밥, 덩이괭이밥 메탄올 추출물의 기능성화장품소재로서의 가능성을 검토하였다. 소재 시험으로 세포독성 시험, 폴리페놀 함량 측정, 항산화 효과 시험, 주름개선 효과 시험 및 미백 효과 시험을 실시하였다. 세포독성 시험 결과 1,000 μg/mL 농도 까지 괭이밥 추출물은 세포독성이 거의 없었다. 괭이밥, 큰괭이밥, 덩이괭이밥 메탄올 추출물은 유효성분으로 폴리페놀의 함량이 각각 116.036 ± 0.37mg/g, 54.72 ± 0.52 mg/g, 88.18 ± 1.15 mg/g로 높은 농도를 나타내었다. DPPH 자유 라디칼 소거 시험을 이용한 항산화 효과 시험결과, 1,000 μg/mL의 농도에서 괭이밥, 큰괭이밥, 덩이괭이밥 메탄올 추출물은 89%, 80%, 88%의 매우 우수한 항산화 효과를 보였다. Elastase 억제 효과 시험을 이용한 주름개선 효과는 1,000 μg/mL 농도에서 괭이밥 81%, 큰괭이밥 51%, 덩이괭이밥 57%를 보였으며, 특히 괭이밥 추출물의 주름개선 효과가 매우 우수하였다. Tyrosinase 억제 시험을 이용한 미백효과는 비교적 낮았다. 괭이밥 추출물 1%를 함유한 로션제의 온도 안정성 시험결과, 큰괭이밥 추출물의 경우 28일 동안 pH, 점도, 외관의 변화가 안정적이고 큰 변화가 없었음을 확인하였으나, 괭이밥 추출물과 덩이괭이밥 추출물의 경우 제형의 개선이 필요하였다. 본 연구로부터 괭이밥 메탄올 추출물은 항산화 효과와 주름개선 효과가 우수하여 주름개선 기능성화장품소재로서 높은 가능성을 보였다.

In this study, methanol extracts of the Oxalidaceae were tested with a potential functional cosmetic agent. As cosmetic agent tests, cell toxicity, polyphenol content, antioxidation, anti-wrinkle, and whitening effects were measured. Cell toxicity of the extracts was weak up to 1,000 μg/mL. Polyphenol contents of Oxalis corniculata L., Oxalis obtriangulata Maximowicz and Oxalis articulata Savigny were 116.036 ± 0.37 mg/g, 54.72 ± 0.52 mg/g and 88.18 ± 1.15 mg/g, respectively. Oxalis corniculata L., Oxalis obtriangulata Maximowicz and Oxalis articulata Savigny extracts showed 89%, 80% and 88% of antioxidation effects at 1,000 μg/mL concentration using DPPH free radical scavenging assay. Oxalis corniculata L., Oxalis obtriangulata Maximowicz and Oxalis articulata Savigny extracts indicated 81%, 51% and 57% of antiwrinkle effects at 1,000 μg/mL concentration using elastase inhibition assay. Oxalis corniculata L. extract was particularly excellent in elastase inhibition effect. Whitening effect using tyrosinase inhibition assay was relatively weak. Lotion formulation including 1% Oxalis obtriangulata Maximowicz extract was stable based on the temperature stability test for 28 days in terms of pH, viscosity and appearance. However, Lotion formulation including 1% Oxalis corniculata L. extract and Oxalis articulata Savigny extract need formulation improvement. From the research, methanol extract of Oxalis corniculata L. seems to be good candidate for antiwrinkle functional cosmetic agent.

Keywords

The oxalidaceae Extracts Functional cosmetic agent Cell toxicity Antiwrinkle Antioxidation

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