Articles & Issues
- Language
- korean
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received May 11, 2018
Accepted June 25, 2018
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
용매증발법을 이용한 Poly-L-Lactic Acid (PLLA) 마이크로스피어 제조
Preparation of Poly-L-Lactic Acid (PLLA) Microspheres by Solvent-Evaporation Method
건양대학교 의료신소재학과, 35365 대전광역시 서구 관저동로 158
Department of Biomedical Materials, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon, Korea
Korean Chemical Engineering Research, August 2018, 56(4), 461-468(8), 10.9713/kcer.2018.56.4.461 Epub 2 August 2018
Download PDF
Abstract
Poly-L-lactic acid (PLLA)를 출발물질로 하여 용매증발법에 의해 마이크로스피어를 제조하고, 제조 변수가 형성된 마이크로스피어의 형상 및 평균 입경에 미치는 영향을 살펴보았다. PVA 수용액의 농도가 1~5 wt%로 증가함에 따라 평균 입경이 370~160 μm으로 감소하다가 7 wt%에서 다시 240 μm으로 증가하였다. 그리고 PVA의 첨가 부피가 10~50 mL 로 증가함에 따라 평균 입경은 370~220 μm으로 감소하였다. 또한 교반속도가 500~1,500 rpm으로 증가함에 따라 평균 입경은 370~110 μm으로 감소하였다. 유기용매로써 dichloromethane과 chloroform을 각각 사용한 경우 평균 입경은 큰 차이를 보이지 않았으며, dichloromethane을 사용한 경우 표면에서 공극이 확인되었으나 chloroform을 사용한 경우 매끈한 형상의 구형입자가 얻어졌다.
Microspheres were prepared by solvent-evaporation method with Poly-L-lactic acid (PLLA) as a starting material, and the effects of preparation variables on microsphere shape and average particle size were investigated. As the concentration of PVA solution increased from 1 to 5 wt%, the average particle size decreased from 370 μm to 160 μm and then increased to 240 μm at 7 wt%. On the other hand, As the addition volume of PVA solution increased from 10 mL to 50 mL, the average particle size decreased from 370 μm to 220 μm. Also, as the stirring speed increased from 500 rpm to 1,500 rpm, the average particle size decreased from 370 μm to 110 μm. When dichloromethane and chloroform were used as organic solvents, respectively, the average particle size did not show any significant difference. However, when dichloromethane was used, voids were observed on the particle surface, but when chloroform was used, smooth spherical particles were obtained.
References
Saralidze K, Koole LH, Knetsch ML, Materials, 3(6), 3537 (2010)
Sansdrap P, Moes AJ, Int. J. Pharm., 98(1-3), 157 (1993)
Park JK, Lee DH, Lee CI, Kang KC, Pyo HB, Shin JS, Adhesion and Interface, 10(1), 11 (2009)
Kwak SH, Hwang SJ, Lee BC, Yakhak Hoeji, 44(6), 511 (2000)
Bodmeier R, Chen H, J. Pharm. Pharmacol., 40, 754 (1988)
Brooks BW, Richmond HN, Colloids Surf., 58(1-2), 131 (1991)
Lee MH, Kim KJ, Eom TJ, Journal of Korea Technical Association of The Pulp and Paper Industry, 44(6), 28(2012).
Chaiyasat P, Chaiyasat A, Teeka P, Noppalit S, Srinorachun U, Energy Procedia, 34, 656 (2013)
Park SJ, Kim SH, Lee JR, Lee HB, Hong SK, Polymer, 27, 449 (2003)
Kemala T, Budianto E, Soegiyono B, Arabian J. Chemistry, 5(1), 103 (2012)
Park SJ, Seok SJ, Korean Chem. Eng. Res., 43(4), 482 (2005)
Hong Y, Gao C, Shi Y, Shen J, Polym. Adv. Technol., 16(8), 622 (2005)
Sansdrap P, Moes AJ, Int. J. Pharm., 98(1-3), 157 (1993)
Park JK, Lee DH, Lee CI, Kang KC, Pyo HB, Shin JS, Adhesion and Interface, 10(1), 11 (2009)
Kwak SH, Hwang SJ, Lee BC, Yakhak Hoeji, 44(6), 511 (2000)
Bodmeier R, Chen H, J. Pharm. Pharmacol., 40, 754 (1988)
Brooks BW, Richmond HN, Colloids Surf., 58(1-2), 131 (1991)
Lee MH, Kim KJ, Eom TJ, Journal of Korea Technical Association of The Pulp and Paper Industry, 44(6), 28(2012).
Chaiyasat P, Chaiyasat A, Teeka P, Noppalit S, Srinorachun U, Energy Procedia, 34, 656 (2013)
Park SJ, Kim SH, Lee JR, Lee HB, Hong SK, Polymer, 27, 449 (2003)
Kemala T, Budianto E, Soegiyono B, Arabian J. Chemistry, 5(1), 103 (2012)
Park SJ, Seok SJ, Korean Chem. Eng. Res., 43(4), 482 (2005)
Hong Y, Gao C, Shi Y, Shen J, Polym. Adv. Technol., 16(8), 622 (2005)
