Articles & Issues
- Language
- korean
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received March 1, 2019
Accepted April 10, 2019
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
LDH 나노입자 기반의 바이오 이미징 소재
Layered Double Hydroxide Nanoparticles for Bio-Imaging Applications
1경남대학교 나노신소재공학과, 51767 경상남도 창원시 마산합포구 경남대학로 7 2주장대학교 화학·환경공학부, 332005 중국 강서성 주장시
1Department of Nano Materials Science and Engineering, Kyungnam University, 7, Gyeongnamdaehak-ro, Masanhappo-gu, Changwon-si, Gyeongsangnam-do, 51767, Korea 2College of Chemistry and Environmental Engineering, Jiujiang University, Jiujiang Jiangxi 332005, P. R. China
Korean Chemical Engineering Research, August 2019, 57(4), 445-454(10), 10.9713/kcer.2019.57.4.445 Epub 2 August 2019
Download PDF
Abstract
Layered double hydroxides (LDHs) 나노입자는 특유의 층상형 결정구조에서 기인된 물리화학적 물성 및 생체친화성을 바탕으로 나노-바이오 분야에서 주목을 받고 있다. 바이오 이미징은 질병의 진단과 치료(테라노스틱스, theranostics=therapy+diagnosis)에 다양하게 활용될 수 있는 핵심적인 분야로 차세대 맞춤의학으로의 새로운 패러다임 실현을 위해서 보다 정확하고 빠른 진단기술이 절실히 요구되고 있다. 이를 실현하기 위한 대안으로 나노기술이 접목된 고감도 분자영상 관련 연구들이 활발히 진행되고 있다. 본 총설에서는 LDH 나노입자를 기반으로 하는 바이오 이미징 시스템의 개발동향에 관하여 소개하고 바이오 이미징에 적합한 나노소재의 구조 및 합성 방법에 대하여 설명하였다. 또한 임상 의학에서 현재 많이 사용되고 있는 형광을 이용한 광학영상, 자기공명영상(MRI), 핵의학영상(PET), 컴퓨터 단층 촬영(CT) 등 다양한 분야에서 어떻게 LDH 나노입자를 이용하여 나노 프로브 개발을 할 수 있는지 연구사례를 기술하면서 나노기술과 첨단영상기술이 융합된 획기적인 고감도 나노 바이오 이미징 시스템 개발 및 그 잠재력에 대하여 전망해 보았다.
Layered double hydroxides (LDHs) nanoparticles have emerged as novel nanomaterials for bio-imaging applications due to its unique layered structure, physicochemical properties, and good biocompatibility. Bio-imaging is one of the most important fields for medical applications in clinical diagnostics and therapeutics of various diseases. Enhanced diagnostic techniques are needed to realize new paradigm for next-generation personalized medicine through nanoscale materials. When nanotechnology is introduced into bio-imaging system, nanoparticle probes can endow imaging techniques with enhanced ability to obtain information about biological system at the molecular level. In this review, we summarize structural features of LDH nanoparticles with current issues of bio-imaging system. LDH nanoparticle probes are also discussed through in vitro as well as in vivo studies in various bio-imaging techniques including fluorescence imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), and computed X-ray tomography (CT), which will have the potential in the development of the advanced nanoparticles with high sensitivity and selectivity.
References
Qian X, Peng XH, Ansari DO, Yin-Goen Q, Chen GZ, Shin DM, Yang L, Young AN, Wang MD, Nie S, Nat. Biotechnol., 26, 83 (2007)
Michalet X, Pinaud FF, Bentoilla LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S, Science, 307, 5838 (2005)
Cao YW, Jin R, Mirkin CA, Science, 297, 1536 (2002)
Weissleder R, Science, 312, 1168 (2006)
Ahrens ET, Bulte JWM, Nat. Rev. Immunol., 13, 755 (2013)
Yang J, Lee CH, Ko HJ, Suh JS, Yoon HG, Lee K, Huh YM, Haam S, Angew. Chem.-Int. Edit., 46, 8836 (2007)
Lee DH, Koo H, Sun IC, Ryu JH, Kim K, Kwon IC, Chem. Soc. Rev., 41, 2656 (2012)
Cheon J, Lee JH, Accounts Chem. Res., 41, 1630 (2008)
Choi JS, Park JC, Nah H, Woo S, Oh J, Kim KM, Cheon GJ, Chang YC, Yoo JY, Cheon J, Angew. Chem.-Int. Edit., 47, 6259 (2008)
Yang J, Lim EM, Lee HJ, Park J, Lee SC, Lee K, Yoon HG, Suh JS, Huh YM, Haam S, Biomaterials, 29, 2548 (2008)
Shin TH, Choi Y, Kim S, Cheon J, Chem. Soc. Rev., 44, 4501 (2015)
Ashton JR, West JL, Badea CT, Front. Pharmacol., 6, 256 (2015)
Yoon YS, Lee BI, Lee KS, Im GH, Byeon SH, Lee JH, Lee IS, Adv. Funct. Mater., 19(21), 3375 (2009)
Park DH, Choi G, Choy JH, Photofunctional Layered Materials, 166, 137 (2015)
Huang G, Zhang KL, Chen S, Li SH, Wang LL, Wang LP, Liu R, Gao J, Yang HH, J. Mater. Chem. B, 5, 3629 (2017)
Shi S, Fliss BC, Gu Z, Zhu Y, Hong H, Valdovinos HF, et al., Sci. Rep., 5, 16930 (2015)
Wei PR, Cheng SH, Liao WN, Kao KC, Weng CF, Lee, CH, J. Mater. Chem., 22, 5503 (2012)
Wang X, Li JG, Zhu Q, Li X, Sun X, Sakka Y, J. Alloy. Compd., 603, 28 (2014)
Cha BG, Kim J, “Functional Mesoporous Silica Nanoparticles for Bio-imaging Applications,” WIREs Nanomed Nanobiotechnol., e1515(2018).
Medintz IL, Uyeda HT, Goldman ER, Mattoussi H, Nat. Mater., 4(6), 435 (2005)
Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN, Chem. Rev., 108(6), 2064 (2008)
Na HB, Song IC, Hyeon T, Adv. Mater., 21(21), 2133 (2009)
Choi JS, Jun YW, Yeon SI, Kim HC, Shin JS, Cheon J, J. Am. Chem. Soc., 128(50), 15982 (2006)
Huang HC, Barua S, Sharma G, Dey SK, Rege K, J. Control. Release, 155, 344 (2011)
Oh JM, Hwang SH, Choy JH, Solid State Ion., 151(1-4), 285 (2002)
Chung HE, Park DH, Choy JH, Choi SJ, Appl. Clay. Sci., 65-66, 24 (2012)
Peng L, Mei X, He J, Xu J, Zhang W, Liang R, Wei M, Evans DG, Duan X, Adv. Mater., 30, 170738 (2018)
Choy JH, Kwak SY, Jeong YJ, Park JS, Angew. Chem.-Int. Edit., 39, 4041 (2000)
Choy JH, Kwak SY, Park JS, Jeong YJ, J. Mater. Chem., 11, 1671 (2001)
Oh JM, Choi SJ, Kim ST, Choy JH, Bioconjugate Chem., 17, 1411 (2006)
Oh JM, Choi SJ, Lee GE, Kim JE, Choy JH, Chem. Asian. J., 4, 67 (2009)
Wei PR, Kuthati Y, Kankala RK, Lee CH, Int. J. Mol. Sci., 16(9), 20943 (2015)
Park DH, Cho J, Kwon OJ, Yun CO, Choy JH, Angew. Chem.-Int. Edit., 55, 4582 (2016)
Li B, Gu Z, Kurniawan N, Chen W, Xu ZP, Adv. Mater., 29, 170037 (2017)
Wang L, Xing H, Zhang S, Ren Q, Pan L, Zhang K, Bu W, Zheng X, Zhou L, Peng W, Hua Y, Shi J, Biomaterials, 34, 3390 (2013)
Guan S, Liang R, Li C, Wei M, Talanta, 165, 297 (2017)
Arratia-Quijada J, Jimenez CS, Gurinov A, Centeno PA, Andrade CI, Arizaga CGG, Mater. Sci. Eng. B-Solid State Mater. Adv. Technol., 203, 7 (2016)
Kim SY, Oh JM, Lee JS, Kim TJ, Choy JH, J. Nanosci. Nanotechnol., 8, 5181 (2008)
Mei X, Wang W, Yan L, Hu T, Liang R, Yan D, Wei M, Evans D, Duan X, Biomaterials, 165, 14 (2018)
Zuo H, Chen W, Li B, Xu K, Cooper H, Gu Z, Xu ZP, Chem. Eur. J., 23, 14299 (2017)
Li B, Tang J, Chen W, Hao G, Kurniawan N, Gu Z, Xu ZP, Biomaterials, 177, 40 (2018)
Kim TH, Lee WJ, Lee JY, Paek SM, Oh JM, Dalton Trans., 43, 10430 (2014)
Xu ZP, Kurniawan ND, Bartlett PF, Lu GQ, Chem. Eur. J., 13, 2824 (2007)
Choy JH, Kwak SY, Park JS, Jeong YJ, Portier J, J. Am. Chem. Soc., 121(6), 1399 (1999)
Choy JH, Choi SJ, Oh JM, Park T, Appl. Clay Sci., 36, 122 (2007)
Oh JM, Park DH, Choi SJ, Choy JH, Recent Pat. Nanotech., 6, 200 (2012)
Mishra G, Dash B, Pandey S, Appl. Clay Sci., 153, 172 (2018)
Oh JM, Choi SJ, Lee GE, Han SH, Choy JH, Adv. Funct. Mater., 19(10), 1617 (2009)
Kurreck J, Angew. Chem.-Int. Edit., 48, 1378 (2009)
Caravan P, Ellison JJ, McMurry TJ, Lauffer RB, Chem. Rev., 99(9), 2293 (1999)
Michalet X, Pinaud FF, Bentoilla LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S, Science, 307, 5838 (2005)
Cao YW, Jin R, Mirkin CA, Science, 297, 1536 (2002)
Weissleder R, Science, 312, 1168 (2006)
Ahrens ET, Bulte JWM, Nat. Rev. Immunol., 13, 755 (2013)
Yang J, Lee CH, Ko HJ, Suh JS, Yoon HG, Lee K, Huh YM, Haam S, Angew. Chem.-Int. Edit., 46, 8836 (2007)
Lee DH, Koo H, Sun IC, Ryu JH, Kim K, Kwon IC, Chem. Soc. Rev., 41, 2656 (2012)
Cheon J, Lee JH, Accounts Chem. Res., 41, 1630 (2008)
Choi JS, Park JC, Nah H, Woo S, Oh J, Kim KM, Cheon GJ, Chang YC, Yoo JY, Cheon J, Angew. Chem.-Int. Edit., 47, 6259 (2008)
Yang J, Lim EM, Lee HJ, Park J, Lee SC, Lee K, Yoon HG, Suh JS, Huh YM, Haam S, Biomaterials, 29, 2548 (2008)
Shin TH, Choi Y, Kim S, Cheon J, Chem. Soc. Rev., 44, 4501 (2015)
Ashton JR, West JL, Badea CT, Front. Pharmacol., 6, 256 (2015)
Yoon YS, Lee BI, Lee KS, Im GH, Byeon SH, Lee JH, Lee IS, Adv. Funct. Mater., 19(21), 3375 (2009)
Park DH, Choi G, Choy JH, Photofunctional Layered Materials, 166, 137 (2015)
Huang G, Zhang KL, Chen S, Li SH, Wang LL, Wang LP, Liu R, Gao J, Yang HH, J. Mater. Chem. B, 5, 3629 (2017)
Shi S, Fliss BC, Gu Z, Zhu Y, Hong H, Valdovinos HF, et al., Sci. Rep., 5, 16930 (2015)
Wei PR, Cheng SH, Liao WN, Kao KC, Weng CF, Lee, CH, J. Mater. Chem., 22, 5503 (2012)
Wang X, Li JG, Zhu Q, Li X, Sun X, Sakka Y, J. Alloy. Compd., 603, 28 (2014)
Cha BG, Kim J, “Functional Mesoporous Silica Nanoparticles for Bio-imaging Applications,” WIREs Nanomed Nanobiotechnol., e1515(2018).
Medintz IL, Uyeda HT, Goldman ER, Mattoussi H, Nat. Mater., 4(6), 435 (2005)
Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN, Chem. Rev., 108(6), 2064 (2008)
Na HB, Song IC, Hyeon T, Adv. Mater., 21(21), 2133 (2009)
Choi JS, Jun YW, Yeon SI, Kim HC, Shin JS, Cheon J, J. Am. Chem. Soc., 128(50), 15982 (2006)
Huang HC, Barua S, Sharma G, Dey SK, Rege K, J. Control. Release, 155, 344 (2011)
Oh JM, Hwang SH, Choy JH, Solid State Ion., 151(1-4), 285 (2002)
Chung HE, Park DH, Choy JH, Choi SJ, Appl. Clay. Sci., 65-66, 24 (2012)
Peng L, Mei X, He J, Xu J, Zhang W, Liang R, Wei M, Evans DG, Duan X, Adv. Mater., 30, 170738 (2018)
Choy JH, Kwak SY, Jeong YJ, Park JS, Angew. Chem.-Int. Edit., 39, 4041 (2000)
Choy JH, Kwak SY, Park JS, Jeong YJ, J. Mater. Chem., 11, 1671 (2001)
Oh JM, Choi SJ, Kim ST, Choy JH, Bioconjugate Chem., 17, 1411 (2006)
Oh JM, Choi SJ, Lee GE, Kim JE, Choy JH, Chem. Asian. J., 4, 67 (2009)
Wei PR, Kuthati Y, Kankala RK, Lee CH, Int. J. Mol. Sci., 16(9), 20943 (2015)
Park DH, Cho J, Kwon OJ, Yun CO, Choy JH, Angew. Chem.-Int. Edit., 55, 4582 (2016)
Li B, Gu Z, Kurniawan N, Chen W, Xu ZP, Adv. Mater., 29, 170037 (2017)
Wang L, Xing H, Zhang S, Ren Q, Pan L, Zhang K, Bu W, Zheng X, Zhou L, Peng W, Hua Y, Shi J, Biomaterials, 34, 3390 (2013)
Guan S, Liang R, Li C, Wei M, Talanta, 165, 297 (2017)
Arratia-Quijada J, Jimenez CS, Gurinov A, Centeno PA, Andrade CI, Arizaga CGG, Mater. Sci. Eng. B-Solid State Mater. Adv. Technol., 203, 7 (2016)
Kim SY, Oh JM, Lee JS, Kim TJ, Choy JH, J. Nanosci. Nanotechnol., 8, 5181 (2008)
Mei X, Wang W, Yan L, Hu T, Liang R, Yan D, Wei M, Evans D, Duan X, Biomaterials, 165, 14 (2018)
Zuo H, Chen W, Li B, Xu K, Cooper H, Gu Z, Xu ZP, Chem. Eur. J., 23, 14299 (2017)
Li B, Tang J, Chen W, Hao G, Kurniawan N, Gu Z, Xu ZP, Biomaterials, 177, 40 (2018)
Kim TH, Lee WJ, Lee JY, Paek SM, Oh JM, Dalton Trans., 43, 10430 (2014)
Xu ZP, Kurniawan ND, Bartlett PF, Lu GQ, Chem. Eur. J., 13, 2824 (2007)
Choy JH, Kwak SY, Park JS, Jeong YJ, Portier J, J. Am. Chem. Soc., 121(6), 1399 (1999)
Choy JH, Choi SJ, Oh JM, Park T, Appl. Clay Sci., 36, 122 (2007)
Oh JM, Park DH, Choi SJ, Choy JH, Recent Pat. Nanotech., 6, 200 (2012)
Mishra G, Dash B, Pandey S, Appl. Clay Sci., 153, 172 (2018)
Oh JM, Choi SJ, Lee GE, Han SH, Choy JH, Adv. Funct. Mater., 19(10), 1617 (2009)
Kurreck J, Angew. Chem.-Int. Edit., 48, 1378 (2009)
Caravan P, Ellison JJ, McMurry TJ, Lauffer RB, Chem. Rev., 99(9), 2293 (1999)
