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Cyclitol 유도체 합성에 관한 연구
Study on the Synthesis of Cyclitol Derivatives-Kinetics of the Reaction of myo-inositol with Carbonyl Compounds-
HWAHAK KONGHAK, April 1971, 9(1), 43-51(9), NONE
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Abstract
The myo-inositol has a very suitable structure for stereochemical study. By the use of carbonyl compounds such as cyclohexanone, acetophenone and furfural, myo-inositol has been into 1, 2-O-substituted derivaties.
The presence of two contiguous hydroxyl groups in ax. -eq. position is necessary for reaction to occur predominantly. In this case, however, di-O-substituted derivatives have been obtained, in other words, contiguous hydroxyl groups in eq. -eq. position have reacted.
The rate constants for the reaction of myo-inositol with carbonyl compounds and activation energys were evaluated.
From the values obtained above, it was found that this reaction was pseudo-first reaction and the order of reaction could be represented as cyclohexanone> acetophenone> furfural.
The presence of two contiguous hydroxyl groups in ax. -eq. position is necessary for reaction to occur predominantly. In this case, however, di-O-substituted derivatives have been obtained, in other words, contiguous hydroxyl groups in eq. -eq. position have reacted.
The rate constants for the reaction of myo-inositol with carbonyl compounds and activation energys were evaluated.
From the values obtained above, it was found that this reaction was pseudo-first reaction and the order of reaction could be represented as cyclohexanone> acetophenone> furfural.
