Overall
- Language
- korean
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
Most Cited
초임계유체를 이용한 입자제조
Design of Particles using Supercritical Fluids
한국과학기술연구원 국가지정 초임계유체연구실, 136-791 서울시 성북구 하월곡동 39-1
National Research Lab for Supercritical Fluids, Korea Institute of Science and Technology, 39-1, Haweolkok-dong, Sungbuk-gu, Seoul 136-791, Korea
supercritical@hanmail.net
HWAHAK KONGHAK, December 2003, 41(6), 679-688(10), NONE
Download PDF
Abstract
초임계이산화탄소와 초임계수와 같은 초임계유체의 환경친화적 성질은 미세입자를 제조하는 새로운 재료분야의 응용에 많은 관심의 대상이 되고 있다. 최근에는 초임계유체의 저독성과 불연성 그리고 저렴한 가격 때문에 의약품, 화장품, 세라믹, 식품 그리고 폭약 등에서 이를 이용하여 나노 또는 마이크로입자를 제조하는 공정에 많은 이용되고 있다. 본고에서는 초임계유체를 이용하여 미세입자를 제조하는 대표적인 공정인 RESS(rapid expansion of supercritical solutions), SAS(supercriticalanti solvent) 그리고 PGSS(particles from gas saturated solutions)등에 대하여 중점적으로 소개하고자 한다.
The environmentally friendly nature of supercritical fluids such as supercritical carbon dioxide and supercritical water has led to the exploration of their use in a range of materials applications. In the last few years, several supercritical fluids-based techniques have been proposed for the production of micronic and nanometric particles for potential applications in areas such as pharmaceuticals, cosmetics, inorganics, biomaterials and explosives. Techniques like the rapid expansion of supercritical solutions (RESS), supercritical antisolvent precipitation (SAS), particle generation from gas-saturated solutions (PGSS), and reactive precipitation in supercritical solutions (RPSS) have been critically reviewed.
Keywords
References
Krukonis V, "Supercritical Fluid Nucleation of Difficult to Comminute Solids," the AIChE Annual Meeting, San Francisco (1984)
Subramaniam B, Rajewski RA, Snavely K, J. Pharm. Sci., 86(8), 885 (1997)
Hanney JB, Hogarht J, Proc. Roy. Soc., 29, 324 (1879)
Jung J, Perrut M, J. Supercrit. Fluids, 20, 179 (2001)
Gallagher PM, Krukonis VJ, Botsaris GD, AIChE Symp. Ser., 82(284), 96 (1989)
Yeo S, Debenedetti PG, Radosz M, Schmidt H, Macromolecules, 26, 6207 (1993)
Benedetti L, Bertucco A, Pallado P, Biotechnol. Bioeng., 53(2), 232 (1997)
Randolph TW, Randolph AJ, Mebes M, Yeung S, Biotechnol. Prog., 9, 429 (1993)
Kajimoto O, Chem. Rev., 99(2), 355 (1999)
Tucker SC, Chem. Rev., 99(2), 391 (1999)
Johannsen M, Brunner G, J. Chem. Eng. Data, 42(1), 106 (1997)
Chrastil J, J. Phys. Chem., 86, 3016 (1982)
McHugh MA, Krukonis VJ, Supercritical Fluid Extraction: Pronciples and Practice, 2nd ed., Butterworth-Heinemann, Boston, MA (1994)
Mohamed RS, Halverson DS, Debenedetti PG, Prud'homme RK, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 355-378 (1989)
Tom JW, Debenedetti PG, J. Aerosol Sci., 22(5), 555 (1991)
Turk M, J. Supercrit. Fluids, 15(1), 79 (1999)
Helfgen B, Turk M, Schaber M, J. Power Sources, 110, 22 (2000)
Chang CJ, Randolph AD, AIChE J., 35(11), 1876 (1989)
Smith RD, Wash R, "Supercritical Fluid Molecular Spray Film Deposition and Powder Formation," U.S. Patent, 4,582,731 (1986)
Perrut M, Jung J, Leboeuf F, French Patent, Application FR-02 05046 (2002)
Gallagher PM, Coffey MP, Krukonis VJ, Klasutis N, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 334-354 (1989)
Gallagher PM, Coffey MP, Krukonis VJ, Hillstrom WW, J. Supercrit. Fluids, 5, 130 (1992)
Gallagher MP, Krukonis VJ, Coffey MP, "Gas Anti-Solvent Recrystallization and Application for the Separation and Subsequent Processing of RDX and HMX," U.S. Patent, 5,389,263 (1992)
Dixon DJ, Johnston KP, AIChE J., 37(10), 1441 (1991)
Dixon DJ, Lunabarcenas G, Johnston KP, Polymer, 35(18), 3998 (1994)
Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP, Pharm. Res., 12(8), 1211 (1994)
Yeo SD, Lim BG, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341 (1993)
Schmitt WJ, Salada MC, Shook GG, Speaker SM, AIChE J., 41(11), 2476 (1995)
Chou YH, Tomasko DL, "GAS Crystallization of Polymer-pharmaceutical Composite Particles," The 4th International Symposium on Supercritical Fluids, May, Sendai, Japan (1997)
Reverchon E, DellaPorta G, DiTrolio A, "Morphological Analysis of Nanoparticles Generated by SAS," Fourth Italian Conference on Supercritical Fluids and Their Applications, September, Capri (1997)
Reverchon E, DellaPorta G, Celano C, Pace S, DiTrolio A, J. Mater. Res., 13(2), 284 (1998)
Amaro-Gonzalez D, Mabe G, Zabaloy M, Brignole EA, J. Supercrit. Fluids, 17(3), 249 (2000)
Chattopadhyay P, Gupta RB, "Supercritical CO2 Based Production of Fullerene Nanoparticles," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Hong L, Bitemo SR, Gao Y, Yuan WK, "Precipitation of Microparticulate Organic Pigment Powders by Supercritical Antisolvent (SAS) Process," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Reverchon E, DeMarco I, DellaPorta G, J. Supercrit. Fluids, 23(1), 81 (2002)
Thiering R, Dehghani F, Foster NR, J. Supercrit. Fluids, 21(2), 159 (2001)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 95/01221 (1994)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 96/00610 (1995)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 98/36825 (1998)
Bustami RT, Chan HK, Dehghani F, Foster NR, "Generation of Protein Micro-Particles using High Pressure Modified Carbon Dioxide," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Novak Z, Senvar-Bozic P, Rizner A, Knez Z, "Particles from Gas Saturated Solution - PGSS," Fluidi Supercriticie Le Loro Applicazioni. E. Reverchon, A. Schiraldi (Eds.), June, Ravello (1993)
Prince WD, Keller GE, Fraser WA, Leung PS, "Spray Application of Plastic Additives to Polymers," EP 590647 (1993)
Sievers RE, Karst U, "Methods and Apparatus for Fine Particle Formation," EP 0677332 (1995)
Weidner E, Steiner R, Knez Z, "Powder Generation from Polyethyleneglycols with Compressible Fluids," the 3rd Int. Sym. on High Pressure Chemical Engineering, October, Zurich (1996)
Sievers RE, Karst U, Milewski PD, Sellers SP, Miles BA, Schaefer JD, Stoldt CR, Xu CY, Aerosol Sci. Technol., 30, 3 (1999)
Sievers RE, Milewski PD, Sellers SP, Miles BA, Korte BJ, Kusek KD, Clark GS, Mioskowski B, Villa JA, "Supercritical and Near-Critical Carbon Dioxide Assisted Low Temperature Bubble Drying," The 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Ventosa N, Veciana J, Rovira C, Sala S, "Method for Precipitating Finely Divided Solid Particles," WO 02/16003 (2002)
Ventosa N, Sala S, Veciana J, Torres J, Llivre J, "Depressurization of an Expanded Liquid Organic Solution (DELOS): A New Procedure for Obtaining Submicron- or Micron-Sized Crystalline Particles," Crystal Growth and Design, 1, 299-303 (2001)
Hakuta Y, Adschiri T, Suzuki T, Chida T, Seino K, Arai K, J. Am. Ceram. Soc., 81(9), 2461 (1998)
Hakuta Y, Onai S, Terayama H, Adschiri T, Arai K, J. Mater. Sci. Lett., 17(14), 1211 (1998)
Lee YW, Theor. Appl. Chem. Eng., 7(1), 705 (2001)
Prober CG, Walson D, Jones J, Pediatrics, 106(6), 89 (2000)
Subramaniam B, Rajewski RA, Snavely K, J. Pharm. Sci., 86(8), 885 (1997)
Hanney JB, Hogarht J, Proc. Roy. Soc., 29, 324 (1879)
Jung J, Perrut M, J. Supercrit. Fluids, 20, 179 (2001)
Gallagher PM, Krukonis VJ, Botsaris GD, AIChE Symp. Ser., 82(284), 96 (1989)
Yeo S, Debenedetti PG, Radosz M, Schmidt H, Macromolecules, 26, 6207 (1993)
Benedetti L, Bertucco A, Pallado P, Biotechnol. Bioeng., 53(2), 232 (1997)
Randolph TW, Randolph AJ, Mebes M, Yeung S, Biotechnol. Prog., 9, 429 (1993)
Kajimoto O, Chem. Rev., 99(2), 355 (1999)
Tucker SC, Chem. Rev., 99(2), 391 (1999)
Johannsen M, Brunner G, J. Chem. Eng. Data, 42(1), 106 (1997)
Chrastil J, J. Phys. Chem., 86, 3016 (1982)
McHugh MA, Krukonis VJ, Supercritical Fluid Extraction: Pronciples and Practice, 2nd ed., Butterworth-Heinemann, Boston, MA (1994)
Mohamed RS, Halverson DS, Debenedetti PG, Prud'homme RK, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 355-378 (1989)
Tom JW, Debenedetti PG, J. Aerosol Sci., 22(5), 555 (1991)
Turk M, J. Supercrit. Fluids, 15(1), 79 (1999)
Helfgen B, Turk M, Schaber M, J. Power Sources, 110, 22 (2000)
Chang CJ, Randolph AD, AIChE J., 35(11), 1876 (1989)
Smith RD, Wash R, "Supercritical Fluid Molecular Spray Film Deposition and Powder Formation," U.S. Patent, 4,582,731 (1986)
Perrut M, Jung J, Leboeuf F, French Patent, Application FR-02 05046 (2002)
Gallagher PM, Coffey MP, Krukonis VJ, Klasutis N, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 334-354 (1989)
Gallagher PM, Coffey MP, Krukonis VJ, Hillstrom WW, J. Supercrit. Fluids, 5, 130 (1992)
Gallagher MP, Krukonis VJ, Coffey MP, "Gas Anti-Solvent Recrystallization and Application for the Separation and Subsequent Processing of RDX and HMX," U.S. Patent, 5,389,263 (1992)
Dixon DJ, Johnston KP, AIChE J., 37(10), 1441 (1991)
Dixon DJ, Lunabarcenas G, Johnston KP, Polymer, 35(18), 3998 (1994)
Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP, Pharm. Res., 12(8), 1211 (1994)
Yeo SD, Lim BG, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341 (1993)
Schmitt WJ, Salada MC, Shook GG, Speaker SM, AIChE J., 41(11), 2476 (1995)
Chou YH, Tomasko DL, "GAS Crystallization of Polymer-pharmaceutical Composite Particles," The 4th International Symposium on Supercritical Fluids, May, Sendai, Japan (1997)
Reverchon E, DellaPorta G, DiTrolio A, "Morphological Analysis of Nanoparticles Generated by SAS," Fourth Italian Conference on Supercritical Fluids and Their Applications, September, Capri (1997)
Reverchon E, DellaPorta G, Celano C, Pace S, DiTrolio A, J. Mater. Res., 13(2), 284 (1998)
Amaro-Gonzalez D, Mabe G, Zabaloy M, Brignole EA, J. Supercrit. Fluids, 17(3), 249 (2000)
Chattopadhyay P, Gupta RB, "Supercritical CO2 Based Production of Fullerene Nanoparticles," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Hong L, Bitemo SR, Gao Y, Yuan WK, "Precipitation of Microparticulate Organic Pigment Powders by Supercritical Antisolvent (SAS) Process," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Reverchon E, DeMarco I, DellaPorta G, J. Supercrit. Fluids, 23(1), 81 (2002)
Thiering R, Dehghani F, Foster NR, J. Supercrit. Fluids, 21(2), 159 (2001)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 95/01221 (1994)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 96/00610 (1995)
Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 98/36825 (1998)
Bustami RT, Chan HK, Dehghani F, Foster NR, "Generation of Protein Micro-Particles using High Pressure Modified Carbon Dioxide," the 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Novak Z, Senvar-Bozic P, Rizner A, Knez Z, "Particles from Gas Saturated Solution - PGSS," Fluidi Supercriticie Le Loro Applicazioni. E. Reverchon, A. Schiraldi (Eds.), June, Ravello (1993)
Prince WD, Keller GE, Fraser WA, Leung PS, "Spray Application of Plastic Additives to Polymers," EP 590647 (1993)
Sievers RE, Karst U, "Methods and Apparatus for Fine Particle Formation," EP 0677332 (1995)
Weidner E, Steiner R, Knez Z, "Powder Generation from Polyethyleneglycols with Compressible Fluids," the 3rd Int. Sym. on High Pressure Chemical Engineering, October, Zurich (1996)
Sievers RE, Karst U, Milewski PD, Sellers SP, Miles BA, Schaefer JD, Stoldt CR, Xu CY, Aerosol Sci. Technol., 30, 3 (1999)
Sievers RE, Milewski PD, Sellers SP, Miles BA, Korte BJ, Kusek KD, Clark GS, Mioskowski B, Villa JA, "Supercritical and Near-Critical Carbon Dioxide Assisted Low Temperature Bubble Drying," The 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Ventosa N, Veciana J, Rovira C, Sala S, "Method for Precipitating Finely Divided Solid Particles," WO 02/16003 (2002)
Ventosa N, Sala S, Veciana J, Torres J, Llivre J, "Depressurization of an Expanded Liquid Organic Solution (DELOS): A New Procedure for Obtaining Submicron- or Micron-Sized Crystalline Particles," Crystal Growth and Design, 1, 299-303 (2001)
Hakuta Y, Adschiri T, Suzuki T, Chida T, Seino K, Arai K, J. Am. Ceram. Soc., 81(9), 2461 (1998)
Hakuta Y, Onai S, Terayama H, Adschiri T, Arai K, J. Mater. Sci. Lett., 17(14), 1211 (1998)
Lee YW, Theor. Appl. Chem. Eng., 7(1), 705 (2001)
Prober CG, Walson D, Jones J, Pediatrics, 106(6), 89 (2000)
