A growing literature within the field of chemical engineering describing the use of artificial neural networks (ANN) has evolved for a diverse range of engineering applications such as fault detection signal processing, process modeling, and control. Because ANN are nets of basis functions, they can provide good empirical models of complex nonlinear processes useful for a wide variety of purposes. This article describes certain types of neural networks that have proved to be effective in practical applications, mentions the advantages and disadvantage of using them, and presents four detailed chemical engineering applications. In the competitive field of modeling, ANN have secured a niche that now, after one decade, seems secure.

Artificial Neural Networks Control Data Rectification Fault Detection Modeling

Barton R, "Analysis and Rectification of Data from Dynamic Chemical Processes via Artificial Neural Networks," Ph.D. Dissertation, Univ. of Texas, Austin, TX (1996)
Billings SA, Voon WSF, Int. J. Control, 44, 235 (1986)
Baum EB, Haussler D, Neural Comput., 1, 151 (1988)
Chen S, Billings SA, Cowan CFN, Grant PM, Int. J. Systems Sci., 21, 2513 (1990)
Cybenko G, Math. Control Signal Syst., 2, 303 (1987)
Draper N, "Straight Line Regression when Both Variables are Subjects to Error," Proceed. 1991 Kansas State Univ. Conf. Appld. Statistics in Agriculture, 1 (1991)
Elman JL, Cognitive Sci., 14, 179 (1990) 
Fiesler E, "Handbook of Neural Computation," Oxford Univ. Press, N.Y. (1996)
Franke R, Constr. Approx., 4, 243 (1988) 
Fine TL, "Feed Forward Neural Network Methodology," Springer, N.Y. (1999)
Fukuoka Y, Matsuki H, Minamitani H, Iskida A, Neural Networks, 11, 1059 (1998) 
Geman S, Bienonstock E, Doursat R, Neural Comput., 4, 1 (1992)
Hertz JA, Krogh AS, Palmer RG, "Introduction to the Theory of Neural Computation," Addison Wesley (1991)
Jang SS, Joseph B, Mukai H, Ind. Eng. Chem. Proc. Dev., 25, 809 (1986) 
Kamruzzaman J, Kumagai Y, Hikitu H, Artificial Neural Networks, 2, 203 (1992)
Karjala TW, "Dynamic Data Rectification via Recurrent Neural Networks," Ph.D. Dissertation, Univ. of Texas, Austin, TX (1995)
Kay JW, Titterington DM, "Statistics and Neural Networks," Oxford Univ. Press, Oxford (2000)
Kim IW, Liebman MJ, Edgar TF, AIChE J., 36, 405 (1990)
Kulawski GJ, Brdys NA, Automatica, 36(1), 5 (2000) 
Lee CC, Chung PC, Tsai JR, Chang CI, IEEE Trans. SMC-Part B. Cybernetics, 29, 674 (1999) 
Lee TC, "Structure Level Adaptation for Artificial Neural Networks," Kluwer Acad. Publ. (1991)
Lippmann RP, IEEE ASSP Magn., 4, 4 (1987)
Ljung L, "System Identification, Theory for the User," Prentice Hall (1987)
Ljung L, Sjoberg J, "A System Identification Perspective on Neural Nets," Proceed. 1992 IEEE Workshop on Neural Nets for Signal Processing, IEEE (1992)
MacMurray JC, "Modeling and Control of a Packed Distillation Column using Artificial Neural Networks," M.S. Thesis, Univ. of Texas, Austin, TX (1993)
Moody J, "Prediction Risk and Architecture Selection for Neural Networks," in From Statistics to Neural Networks, eds. V. Cherkassky, J.H. Friedman, and H. Wechsler, Springer Verlag, Berlin, 147 (1994)
Patwardhan AA, "Modeling and Control of a Packed Distillation Column," Ph.D. Dissertation, Univ. of Texas, Austin, TX (1991)
Psichogious D, Unger L, AIChE J., 38, 1499 (1992) 
Reed R, IEEE Trans. Neural Networks, 4, 740 (1993) 
Rumerhart DE, McClelland JL, "Parallel Distributed Processing," MIT Press, 1 (1986)
Seinfeld JH, AIChE J., 16, 1016 (1970) 
Sjoberg J, Ljung L, "Overtraining, Regularization, and Searching for a Minimum in Neural Networks," in Preceed. IFAC Symp. Adaptive Systems in Control and Signal Processing, IFAC, 669 (1992)
Soderstrom T, Automatica, 17, 713 (1981) 
Suewatanakal W, "A Comparison of Fault Detection and Classification using ANN with Traditional Methods," Ph.D. Dissertation, Univ. of Texas, Austin, TX (1993)
van de Laar P, Heskes T, Neural Comput., 11, 977 (1999) 
Werbos PJ, Proceed. IEEE, 78, 1550 (1990) 
Aldrich C, Deventer J, "Artificial Intelligence Methods for Process Monitoring and Modelling of Metallurgical Plant," Proceedings of PSE '94, 1297 (1994)
Aguiar HCIL, Filho RM, Comput. Chem. Eng., 22(S), 981 (1998) 
Aldrich C, Deventer J, Canadian J. Chem. Eng., 73, 808 (1995)
Aldrich C, Moolman D, Deventer J, Comput. Chem. Eng., 19(S), 803 (1995) 
Alvarez E, Riverol C, Correa JM, Navaza JM, Ind. Eng. Chem. Res., 38(4), 1706 (1999) 
Alvarez E, Riverol C, Navaza JM, ISA Transactions, 38, 375 (1999) 
Aly A, Peralta R, Water Resour. Res., 8, 2523 (1999) 
Anderson JS, Kevrekidis IG, Rico-Martinez R, Comput. Chem. Eng., 20(S), 751 (1996) 
Arena P, Baglio S, Castorina C, Fortuna L, Nunnari G, "A Neural Architecture to Predict Pollution in Industrial Areas," Proceedings of ICNN Wash. D.C. June 2, 1996, 2107 (1996)
Baratti R, Vacca G, Servida A, Hydrocarb. Process., June, 35 (1995)
Barsamian A, Macias J, Hydrocarb. Process., October, 107 (1998)
Barton RS, Himmelblau DM, "On-Line Prediction of Polymer Product Quality in an Industrial Reactor Using Recurrent Neural Networks," Proc. International Neural Networks, Houston, TX June, 1997, 111 (1997)
Baughman D, "Neural Networks in Bioprocessing and Chemical Engineering," Ph.D. Dissertation, Virginia Polytechnic Institute and State University (1995)
Bawazeer K, Zilouchian A, "Prediction of Products Quality Parameters of a Crude Fractionation Section of an Oil Refinery Using Neural Networks," Proceedings of ICNN Houston, 157 (1997)
Bhat N, Minderman P, McAvoy T, "Use of Neural Nets for Modeling of Chemical Process Systems," IFAC Dynamics and Control of Chemical Reactors (DYCORD 89), 169 (1989)
Biegler-Konig F, Barmann F, Chem. Ing. Tech., 63, 64 (1991) 
Birky G, McAvoy T, "A Neural Net to Learn the Design of Distillation Controls," IFAC Dynamics and Control of Chemical Reactors (DYCORD 89), 205 (1989)
Bittanti S, Piroddi L, J. Franklin Institute, 3343, 135 (1997) 
Blum J, Villard P, Leuba A, Karjala T, Himmelblau DM, "Practical Issues in Applying Artificial Neural Network for Identification in Model Based Predictive Control," Proc. World Conf. Neural Networks, San Diego, CA, June, II, 135 (1994)
Blum J, Villard P, Leuba A, Karjala T, Himmelblau DM, "Practical Issues in Applying Artificial Neural Network for Identification in Model Based Predictive Control," Proceed. World Conference on Neural Networks, San Diego, CA, June (1994)
Bochereau L, Bourgine P, Bouyer F, Muratet G, "Using Recurrent Multilayer Neural Networks for Simulating Batch Reactors," Proceedings of IJCNN Singapore, 1510 (1991)
Bogdan S, Gosak D, Vasic-Racki D, Comput. Chem. Eng., 19(S), 791 (1995) 
Bohr H, "Neural Networks for Protein Structure Prediction," In Scientific Applications of Neural Nets, J.W. Clark, ed., Springer, Berlin, 189 (1999)
Borges L, Castier M, "Evaluation of the Thermodynamic Models Uniquac and Unifac Using Artificial Neural Networks," Proceedings of 1993 International Joint Conference on Neural Networks, 999 (1993)
Brambilla A, Trivella F, Hydrocarb. Process., 61 (1996)
Bravi M, Chianese A, Mustacchi C, Sed M, Zhang J, "A Neural Network for Crystallizer Dynamics," Chaos Fractals Chem. Eng., G. Biardi ed., World Scien. Publ. Singapore, 284 (1995)
Bulsari A, Palosaari S, "System Identification of an Adsorption Process Using Neural Networks," Proceedings of Ad Chem-Kyoto 1994, 53 (1994)
Bulsari A, Saxen H, "Application of Feed-forward Neural Networks for System Identification of a Biochemical Process," Proceedings of IJCNN Singapore 1991, 1222 (1991)
Bulsari A, Saxen H, "Implementation of Heuristics for Chemical Reactor Selection in a Feed-Forward Neural Network," Artificial Neural Networks, T. Kohoren ed., Elsevier, 435 (1991)
Bungay H, Clark J, Chem. Eng. Commun., 125, 105 (1993)
Burns JA, "Application of Feed-forward Neural Networks to Problems in Chemistry," Ph.D. Dissertation, Harvard University (1993)
Cai S, Toral H, "Flow Rate Measurement in Air-Water Horizontal Pipeline by Neural Networks," Proceedings of 1993 International Joint Conference on Neural Networks, 2013 (1993)
Cai S, Toral H, Qiu J, Archer J, Canadian J. Chem. Eng., 72, 440 (1994)
Calderon Z, Espuna A, Puigjaner L, Comput. Chem. Eng., 22(S), 977 (1998) 
Chen FZ, Wang XZ, Ind. Eng. Chem. Res., 37(10), 3985 (1998) 
Chen Y, Himmelblau DM, "Determination of Nonlinear Dynamic Model Order by False Nearest Neighbor Method," Proceed World Congress on Neural Networks, Washington, DC, July (1995)
Cheng Y, Himmelblau DM, "Identification of Nonlinear Process with Dead Time by Recurrent Neural Networks," Proceed 1995 Amer. Control Conf., Seattle, WA, June (1995)
Cheng Y, Karjala TW, Himmelblau DM, Neural Networks, 10, 573 (1997) 
Cheng Y, Karjala TW, Himmelblau DM, Ind. Eng. Chem. Res., 34(5), 1735 (1995) 
Cheng Y, Karjala TW, Himmelblau DM, Comput. Chem. Eng., 20(10), 1159 (1996) 
Cheng Y, Karjala TW, Himmelblau DM, Ind. Eng. Chem. Res., 34(5), 1735 (1995) 
Chessari C, McKay B, Agamennoni O, Barton G, Romagnoli J, "The Application of Neural Networks in the Development of an Online Model for a Semi-Regenerative Catalytic Reformer," Proceedings of World Congress on Neural Networks-San Diego 1994, I-173 (1994)
Christo FC, Masri AR, Nebot EM, "Utilising Artificial Neural Network and Repro-Modelling in Turbulent Combustion," Proceedings of ICNN, 1995, 911 (1995)
Aguiar HCIL, Filho RM, Comput. Chem. Eng., 22(S), 981 (1998) 
Dutta P, Rhinehart R, ISA Transactions, 38, 251 (1999) 
Fakhr-Eddine K, Cabassud M, Duverneuil P, Lann MV, Le C, Comput. Chem. Eng., 20(S), 521 (1996) 
Fileti A, Pereira AF, Comput. Chem. Eng., 21(S), 1227 (1997)
Takeshi F, Kenichiro S, Iori H, Yoshifumi T, Nakamura J, Tsuto K, "Development of Operation Support System for a Hydrolysis Reactor of Fat or Oil - A Neural Network Approach," Proceedings of PSE 1991 Montebello, Quebec, 9.1 (1991)
Fullana M, Trabelsi F, Recasens F, Chem. Eng. Sci., 55(1), 79 (2000) 
Gemmingen U, Chem. Ing. Tech., 63, 64 (1991) 
Gonzalez-Garcia R, Comput. Chem. Eng., 22(S), 965 (1998) 
Grondin-Perez B, Defaye G, Regnier N, Caralp L, Prog. Gence Procedes, 9, 39 (1995)
Gu Z, Lam H, Dhurjati P, Comput. Chem. Eng., 20(S), 407 (1996) 
Guimaraes PRB, McGreavy C, Comput. Chem. Eng., 19(S), 741 (1995) 
Hadjuski M, Elenkov G, Hadjuski L, Mohadjer A, "Neural Network Based Steady-State Observation and Reference Control of Distillation Columns," Proceedings of IFAC Symposium on Dynamics and Control of Chemical Reactors, Distillation Columns and Batch Processes College Park, MD 1992, 393 (1992)
Hanzevack EL, Long TW, Menousek JF, Chem. Eng. Commun., 41 (1993)
Himmelblau DM, Hsiung JT, "Development of Control Strategies via Artificial Neural Networks and Reinforcement Learning," Proceed 1991 ACC, Boston, MA (1991)
Himmelblau DM, "Fault Detection and Diagnosis Via Neural Networks," Neural Networks in Process Engineering. Eds. G.A. Montague and M.J. Willis, IOP Publ., Philadelphia, PA (1994)
Himmelblau DM, "Fault Detection in Heat Exchangers," Proceed Amer. Control. Conf. Chicago, IL, June 23-26 (1992)
Himmelblau DM, "Neural Networks and Chemical Engineering," Proceedings of 15(th) Intl. Conf. Chemical Engineering Industry, Paris, France (1989)
Himmelblau DM, "Rectification of Data in Dynamic Processes Using Artificial Neural Networks," Proc. Conf. Process Systems Engr., Kyongju, Korea, May, 623 (1994)
Himmelblau DM, "Use of Artificial Neural Networks to Monitor Faults and For Troubleshooting in the Process Industries," Proceed. IFAC Conference on On-Line Fault Detection and Supervision in the Chem. Process Industries, University of Delaware, Newark DE, April, 22-24 (1992)
Himmelblau DM, Bhalodia M, "On-Line Sensor Validation of Single Sensors Using Artificial Neural Network," Proceedings of American Control Conference, Seattle, WA, June (1995)
Himmelblau DM, "On-Line Validationof Single Sensors Using Artificial Neural Networks," Proceed 1995 Amer. Control Conference, Seattle, WA, June (1995)
Himmelblau DM, Karjala TW, Comput. Chem. Eng., 20(6-7), 805 (1996) 
Himmelblau DM, Barker RW, Suewatanakul W, "Fault Classification With the Aid of Artificial Neural Networks," Proceed IFAC Conf. Fault Detection, Supervision & Safety, Baden-Baden, Sept. 10-13 (1991)
Hoskins JC, Himmelblau DM, Comput. Chem. Eng., 12, 610 (1988)
Hoskins JC, Himmelblau DM, "Automatic Process Control Using Reinforcement Learning in Artificial Neural Networks," Proceed. 1(st) Annual Meet. Intl. Neural Network Soc. (1988)
Hoskins JC, Himmelblau DM, "Fault Detection and Diagnosis Using Artificial Neural Networks," Artificial Intelligence in Process Engineering, Ed. M. Mavrovouniotis, Academic Press, NY (1991)
Hoskins JC, Himmelblau DM, "Fault Detection and Diagnosis Using Artificial Neural Networks," Artificial Intelligence in Process Engineering, Academic Press, San Diego, CA (1992)
Hoskins JC, Himmelblau DM, "Fault Detection via Artificial Neural Networks," Computer Applns. For the Chemical Industry, R. Eckermann, ed., Dechema, Frankfurt, 116, 227 (1989)
Hoskins JC, Himmelblau DM, Comput. Chem. Eng., 16, 241 (1992) 
Hoskins JC, "Automatic Process Control Using Reinforcement Learning in Artificial Neural Networks," Proceedings of First Annual Meeting International Neural Network Society, Boston, MA (1988)
Hoskins JC, Mavrovouniotis ML, "Fault Detection and Diagnosis Using Artificial Neural Networks," Artificial Intelligence in Process Engineering, Academic Press, 123 (1990)
Hoskins JC, Kaliyur JC, Himmelblau DM, AIChE J., 37, 137 (1991) 
Hoskins JC, Kaliyur KM, Himmelblau DM, "Incipient Fault Detection and Diagnosis Using Artificial Neural Networks," Proceedings of IJCNN90, San Diego (1990)
Huang YL, Edgar TF, Himmelblau DM, Trachtenberg I, IEEE Trans. Semicond. Manuf., 7, 333 (1994) 
Hwarng H, Chong C, "ART-based Control Chart Pattern Recognizers," Proceedings of WCNN Korea, 1994, I-496 (1994)
Iordache O, Corriou JP, Garrido-Sanchez L, Fonteix C, Tondeur D, Comput. Chem. Eng., 17, 1101 (1993) 
Ishida M, Zhan J, "A Policy-and Experience-Driven Neural Network (Penn) and its Application to SISO and MIMO Process Control," Proceedings of International Joint Conference on Neural Networks, 681 (1993)
Ishida M, Zhan J, AIChE J., 41(10), 2333 (1995) 
Jaramillo-Mendez N, Embid-Droz S, Fernandez-Rodriguez B, Lake L, "Estimation of Capillary Pressure and Relative Permeability Using Artificial Neural Networks," Proceedings Annie, 1998, 8, 521 (1998)
Jeong S, Lee KS, HWAHAK KONGHAK, 31(1), 54 (1993)
Joseph B, Hanratty F, Ind. Eng. Chem. Res., 32, 1951 (1993) 
Kargupta H, Ray S, "Temporal Sequence Processing Based on the Biological Reaction-Diffusion Process," Proceedings WCNN Korea, 1994, 150 (1994)
Karim MN, Rivera SL, "Application of Neural Networks in Bioprocess State Estimation," Proceedings of ACC 1992, WA 14, 495 (1992)
Karjala T, Himmelblau DM, "Dynamic Data Rectification Using the Extended Kalman Filter and Recurrent Neural Networks," Proc. IEEE Intl. Conf. Neural Networks, Orlando, FL, June 25, 3244 (1994)
Karjala TW, Himmelblau DM, AIChE J., 42(8), 2225 (1996) 
Karjala TW, Himmelblau DM, "Dynamic Rectification of Process Measurements Containing Either Uncorrelated or Autocorrelated Errors Using Externally Recurrent Networks," Proceed. First Intl. Chemometrics Internet Conference, August (1994)
Karjala TW, Himmelblau DM, "Estimation of Measurement Biases Using Recurrent Neural Networks and the Extended Kalman Filter," Proceed. World Congress Neural Networks, Washington DC, July (1995)
Karjala TW, Himmelblau DM, AIChE J., 40(11), 1865 (1994) 
Karjala TW, Himmelblau DM, "Estimation of Measurement Biases Using Recurrent Neural Networks and Extended Kalman Filter," Proceed. of International Federation of Automatic Control, M265, San Francisco, CA (1996)
Karjala TW, Himmelblau DM, Miikkulainen R, "Data Rectification Using Recurrent (Elman) Neural Networks," Proceed. Intl. Joint Conference on Neural Networks, Baltimore, MD, June 8-10 (1992)
Keeler J, "Prediction and Control of Chaotic Chemical Reactions Via Neural Network Models," Proceedings of Conference on Artificial Intelligence in Petroleum Exploration and Production Plano, TX May 1993, 1 (1993)
Keeler J, SPIE, 1709, 447 (1992) 
Keller P, Kouzes R, Kangas L, "Neural Network Based Chemical Sensor Systems for Environmental Monitoring," Proceedings of WCNN Korea 1994, 269 (1994)
Keshavaraj R, Tock R, Narayan R, Ind. Eng. Chem. Res., 34(11), 3974 (1995) 
Kiparissides C, Morris J, "Intelligent Manufacturing of Polymers,", 20(S), 1113 (1996)
Koiranen T, Comput. Chem. Eng., 22(S), 997 (1998) 
Kraslawski A, Pedrycz W, Koiranen T, Nystrom L, Chem. Eng. Technol., 19(3), 233 (1996) 
Krishnapura V, Jutan A, Canadian J. Chem. Eng., 75, 574 (1997)
Krothapally M, Palanki S, ISA Transactions, 38, 383 (1999) 
Kuroda C, Kag. Kog., 59, 408 (1995)
Kuroe Y, Kimura I, "Modeling of Unsteady Heat Conduction Field by Using Composite Recurrent Neural Networks," Proceedings of ICNN, 1995, 323 (1995)
Kurtanjek Z, Comput. Chem. Eng., 18(S), 627 (1994) 
Lambert J, Hecht-Nielsen R, "Application of Feedforward and Recurrent Neural Networks to Chemical Plant Predictive Modeling," Proceedings of IJCNN Seattle IEEE, I-373 (1991)
Langonnet P, SPIE, 1709, 468 (1992) 
Latrille E, Corrieu G, Thibault J, Comput. Chem. Eng., 18(11-12), 1171 (1994) 
Lee J, Yum C, Kim W, "Neural Network Based Judgmental Adjustment for Time Series Forecasting," Proceedings of EANN Helsinbu August 1995, 299 (1995)
Lei JJ, "The Model Reference Adaptive Control Based on the Genetic Algorithm," Proceedings of ICNN Houston, 1997, 783 (1995)
Lei J, He G, Jiang J, "The State Estimation of the CSTR System Based on a Recurrent Neural Network Trained by HGAs," Proceedings of IEEE, 779 (1997)
Lin J, Jang S, Ind. Eng. Chem. Res., 37(9), 3640 (1998) 
Lin J, Jang S, Shieh S, Subramaniam M, Ind. Eng. Chem. Res., 38(12), 4700 (1999) 
Liu H, Xiaoming X, Zhang Z, "CMAC-Based Learning Control for a Batch Reactor," Proceedings of IFAC Triennial World Congress San Francisco 1996, 385 (1996)
Loh A, Looi K, Fong K, J. Process Control, 5(6), 355 (1995) 
MacMurray JC, Himmelblau DM, Comput. Chem. Eng., 19(10), 1077 (1995) 
Madison M, "Application of Neural Networks to Structure Elucidation," Ph.D. Dissertation, Arizona State University (1992)
Martinetz T, Poppe T, "A Neural Network Approach to Extimating Material Properties," Proceedings WCNN Korea, 1994, 541 (1994)
Martinez E, Wilson J, Comput. Chem. Eng., 22(S), 893 (1998) 
Martinez R, Anderson J, Kevrekidis I, Comput. Chem. Eng., 20(S), 1089 (1996) 
Matsumoto H, Kuroda C, Palosaari S, Ogawa K, J. Chem. Eng. Jpn., 32(1), 1 (1999) 
McAnany D, "Practical Applications of Artificial Neural Networks in Chemical Procees Development," Proceedings of ISA 1993, Paper#93-412, 1721 (1993)
McAvoy T, Pan D, "Application of Olfactory Neural Networks to Chemical Proceeses," Proceedings of PSE 1994, 1025 (1994)
Meert K, Rijckaert S, Comput. Chem. Eng., 22(S), 587 (1998) 
Megan L, Cooper D, Ind. Eng. Chem. Res., 33(6), 1510 (1994) 
Meghlaoui A, Thibault J, Bui R, Tikasz L, Santerre R, Comput. Chem. Eng., 22(10), 1419 (1998) 
Milanic S, Hvala N, Strmcnik S, Karba R, "A Semi-Empirical and a Neural Network Model of a Batch Plant Dynamics for Flexible Recipes Control," DYCOPS-5 Greece June 1998, 292 (1998)
Montague G, Tham M, Willis M, Morris A, "Predictive Control of Distillation Columns Using Dynamic Neural Networks," Proceedings of 3(rd) IFAC Symposium Dynamics Control Chem. Reactors, Distillation Batch Process, College Park, MD April 1992, 231 (1992)
Munsif HP, "Applications of Neural Networks for Distillation Control," Ph.D. Dissertation, Texas Tech University (1996)
Nikravesh M, Soroush M, Johnston R, "Nonlinear Control of an Oil Well," Proceedings of the American Control Conference Albuquerque NM June 1997, 739 (1997)
Noid D, Darsey J, Sumpter B, "Applications of Neural Networks in Polymer Simulations," Soc. Plastic Eng. Meeting New Orleans March 1993, 22 (1993)
Otto M, "Neural Networks for Calibration of Unspecific Chemical Sensors," Proceedings of WCNN Portland, July 11-15 , 1993, 346 (1993)
Palau A, Delgado A, Velo E, Puigjaner L, Comput. Chem. Eng., 20(S), 297 (1996) 
Park JK, "Modeling of Distillation Column and Reactor Dynamics Using Artificial Neural Networks," Ph.D. Dissertation, Northwestern University (1993)
Petersen R, Fredenslund A, Rasmussen P, Comput. Chem. Eng., 18(S), 63 (1994) 
Piron E, Latrille E, Rene F, Comput. Chem. Eng., 21(9), 1021 (1997) 
Prevost P, Isambert A, Depeyre D, Donadille C, Perisse R, Comput. Chem. Eng., 18(11-12), 1157 (1994) 
Qian Y, "Artificial Neural Network for Dynamic Simulation of a CTMP Process," Proceedings of the 3(rd) International Conference on Fuzzy Logic Iizuka Japan, August, 1994, 107 (1994)
Qin S, Rajagopal B, "Combining Statistics and Expert Systems with Neural Networks for Empirical Process Modeling," Proceedings of ISA 1993, 93 (1993)
Raju G, Cooney C, AIChE J., 44(10), 2199 (1998) 
Ramasamy S, Deshpande P, "Consider Neural Networks for Process Identification," Hydrocarbon Processing, 59-62 June (1995)
Ramchandran B, "Neural Network Model-Based Control of Distillation Columns," Ph.D. Dissertation, Texas Tech University (1994)
Ramchandran S, Rhinehart R, J. Process Control, 5(2), 115 (1995) 
Reddy V, Comput. Chem. Eng., 20(S), 889 (1996) 
Rehbein D, Maze S, Havener J, ISA Transactions, 31, 7 (1992)
Reifman J, Vitela J, Feldman E, Wei T, "Recurrent Neural Networks for NOx Prediction in Fossil Plants," Proceedings of Society of Computer Simulation, April (1993)
Reuter M, Chem. Eng. Sci., 48, 1281 (1993) 
Riddle A, Bhat N, Hopper J, "Neural Networks Help Optimize Solvent Extraction," Hydrocarbon Processing, Nov., 45 (1998)
Rivals I, Personnaz P, Dreyfus G, Ploix J, Prog. Genie Procedes, 9, 1 (1995)
Rivera S, "Neural Networks and Micro-Genetic Algorithms for State Estimation and Optimization of Bioprocesses," Ph.D. Dissertation, Colorado State University (1992)
Roj E, Wilk M, Comput. Chem. Eng., 22(S), 909 (1998) 
Savkovic-Stevanovic J, "Neural Networks in Dynamic Simulation and Control of Chemical Systems," Proceed EANN Helsinki 1995, 489 (1995)
Savkovic-Stevanovic J, Comput. Chem. Eng., 47, 411 (1993) 
Savkovic-Stevanovic J, Comput. Chem. Eng., 18(11-12), 1149 (1994) 
Saynatjoki P, Hammarstrom L, "Identification of a Pilot Plant Reactive Distillation Process Using RBF Networks," 4(th) IFAC Symposium Proc. Dyn. Control Chem React. Distill. Col. Batch Processes, 105 (1995)
Schenker B, IEEE Transactions, 6, 388 (1998)
Schenker B, Agarwal M, "State Prediction for Chemical Reactors Using Feedback Neural Networks," DYCORD Maryland 1992, 69 (1992)
Schenker B, Agarwal M, "State Prediction for Chemical Reactors Using Feedback Neural Networks," 3(rd) IFAC Symposium on Dynamics and Control of Chemical Reactors Distillations and Batch Processes, 171 (1992)
Schmitz G, Aldrich C, Comput. Chem. Eng., 22(S), 1001 (1998) 
Shahrokhi M, Pishvaie M, "Artificial Neural Network Feedforward/Feedback Control of a Batch Polymerization Reactor," Proceedings of the American Control Conference June 1994, 3391 (1998)
Shene C, Diez C, Bravo S, Comput. Chem. Eng., 23(8), 1097 (1999) 
Shimizu Y, J. Chem. Eng. Jpn., 32(1), 51 (1999) 
Song J, Park S, J. Chem. Eng. Jpn., 26(4), 347 (1993) 
Souza M, "Neural Net Based Model Predictive Control of a Chaotic Continuous Solution Polymerization Reactor," Proceedings of International Joint Conference on Neural Networks 1993, 1777 (1993)
Su H, Fan L, Schlup J, "On-Line Determination of the Degree of Cure of Epoxy/Graphite Composites With Neural Networks," ISPE Snowmass July 1995, 1 (1995)
Suewatanakul W, Himmelblau DM, Eng. Simulation, 13, 967 (1996)
Terry PA, Himmelblau DM, Ind. Eng. Chem. Res., 32, 3020 (1993) 
Tholudur A, Ramirez W, AIChE J., 45(8), 1660 (1999) 
Tojima M, Suzuki T, Kobayashi G, Minami Y, Tetsu Hagane, 80, 551 (1994)
Tsai C, Chang C, Comput. Chem. Eng., 19(S), 747 (1995) 
Tsaptsinos D, Leigh J, "A Step by Step Approach for the Construction of a Fermentation Process Estimator," Proceedings WCNN Portland, July 11-15, 1993, 216 (1993)
Tsen A, Jang S, Wong D, Joseph B, AIChE J., 42(2), 455 (1996) 
Van Deventer J, "The Tracking of Changes in Chemical Processes Using Computer Vision and Self-Organizing Maps," Proceedings of ICNN, 1995, 3068 (1995)
Van Deventer J, Comput. Chem. Eng., 20(S), 1095 (1996) 
Wang H, Yoon E, "Adaptive Control of Nonlinear Chemical Processes Using Neural Networks," DYCOPS-5 Cortu Greece IFAC, 286 (1998)
Wang H, Oh Y, Yoon E, Comput. Chem. Eng., 22(S), 823 (1998) 
Watanabe K, Hirota S, Hou L, Himmelblau DM, AIChE J., 40(5), 839 (1994) 
Watanabe K, Matsuura I, Abe M, Kubota M, Himmelblau DM, AIChE J., 35, 1803 (1989) 
Whaley A, Bode C, Ghosh J, Eldridge R, "HETP and Pressure Drop Prediction for Structured Packing Distillation Columns Using a Neural Network Model," Proceedings of Annie, 8, 669 (1998)
Willis M, Massimo C, Montague G, Tham M, Morris A, IEE Proceedings Part D, 138, 256 (1991)
Wilson J, Martinez E, Comput. Chem. Eng., 21(S), 1233 (1997)
Wong I, Lam D, Storey A, Fong P, Swayne D, "A Neural Network Approach to Predict Missing Environmental Data," Proceedings WCNN Korea, 1994, 490 (1994)
Xiarong H, Xiaoguang Z, Bingzhen C, "On-Line Estimation of Vapour Pressure of Stabilized Gasoline via ANNs," Proceed EANN Helsinki August 1995, 609 (1995)
Yang S, Wang J, Wang S, "Optimal Blending System of Gasoline Basing Artificial Neural Network," Proceedings of PSE 1994, 1021 (1994)
Zbicinski I, Strumillo P, Kaminski W, Comput. Chem. Eng., 20(S), 695 (1996) 
Zexin H, Xiwen L, Huaqing M, Huagong Xuebao, 46, 144 (1995)
Zhang B, May G, "Towards Real-Time Fault Identification in Plasma Etching Using Neural Networks," Proceedings ANNE 1998, 8, 803 (1998)
Zhang J, Morris A, IEE Proc-Control Theory, 142, 551 (1995) 
Zhang J, Martin E, Morris A, Kiparissides C, Comput. Chem. Eng., 21(S), 1025 (1997)
Zhang J, Morris A, Martin E, Comput. Chem. Eng., 22(7-8), 1051 (1998) 
Zhao H, McAvoy T, "Modeling of Activated Sludge Wastewater Treatment Processes Using Integrated Neural Networks and a First Principle Model," 1996 IFAC 13 Triennial World Congress San Francisco, 455 (1996)
Zhong W, Yu J, Hydrocarb. Process., 77 (1999)
Zhou J, Zhihong X, Leming S, Zhang Y, Cai S, Huagong Yejin, 14, 57 (1993)
Zhu J, Zhengzhi H, Xiao J, Rao M, "Modeling Liquid Phase Oxygenation Process Using Neural Network," Proceedings of ICNN, Houston, 1997, 844 (1997)