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- In relation to this article, we declare that there is no conflict of interest.
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Received November 28, 2007
Accepted December 19, 2007
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재결정 PLGA와 단량체를 이용한 5-FU/PLGA 웨이퍼의 방출거동
Release Behavior of 5-FU from 5-FU/PLGA Wafer using Recrystallized PLGA and Monomer
Jung Soo Park
Myoung Kyu Choi
Yun Tae Kim
Jun Hee Lee
Jong Hyun Mo
Gilson Khang†
John Moon Rhee
Hyung Shik Shin
Hai Bang Lee1
전북대학교 BK21 고분자 BIN 융합 연구팀, 561-756 전북 전주시 덕진구 덕진동1가 664-14 1한국화학연구원 생체분자전달제어팀, 305-600 대전시 유성구 장동 100
BK21 Polymer BIN Fusion Research Team, Chonbuk National University, 664-14 1-ga, Deokjin-dong, Deokjin-gu, Jeonju, Jeonbuk 561-756, Korea 1Nanobiomaterials Lab, KRICT, 100 Jang-dong, Yuseong-gu, Daejon 305-60, Korea
gskhang@chonbuk.ac.kr
Korean Chemical Engineering Research, April 2008, 46(2), 205-210(6), NONE Epub 29 May 2008
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Abstract
PLGA는 생분해성 고분자이며 생체적합성을 갖는 고분자로서 약물전달을 위한 연구에 많이 이용되고 있는 고분자이다. 그러나 PLGA를 약물전달에 이용할 때 약물의 급격한 초기방출 이후에 일정기간동안 약물이 방출되지 않는 지연시간이 존재하게 된다. 이러한 문제를 해결하기 위하여 PLGA 웨이퍼에 단량체를 첨가하여 제조하였다. 또한 PLGA를 재결정하여 약물의 급격한 방출 현상을 억제하도록 하였다. SEM을 이용하여 재결정된 PLGA의 형태학적 차이를 관찰하였으며 생체외 약물 방출거동은 HPLC를 이용하여 측정하였다. PLGA의 분해과정에서 단량체의 영향을 알아보기 위하여 GPC를 이용하여 분자량 변화를 측정하였다. 본 연구를 통하여 PLGA의 벌크분해에 기인한 지연시간을 없앨 수 있었으며 약물의 방출 기간을 3일까지 앞당길 수 있었다.
Poly(D,L-lactide-co-glycolide) (PLGA) has been widely used as carriers in controlled release delivery systems due to its biodegradability and relatively good biocompatibility. However, Release pattern of carriers fabricated using PLGA have disadvantage an initial burst within a few days, lag time several days and then sudden release changes. To solve these problems of PLGA, we fabricated PLGA wafer including monomer. Also, drug release behavior restraint sudden burst effect using recrystallization of PLGA. Recrystallized PLGA was characterized the morphological difference by SEM and in vitro release behavior measured by HPLC. The PLGA molecular weight analyzed to recognize monomer influence during degradation process of polymer using GPC. In this study, drug release duration cut short up to three days and was eliminated the lag time based on the bulk erosion.
Keywords
References
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Khang G, Choi HS, Rhee JM, Yoon SC, Cho JC, Lee HB, Korea Polym. J., 8(6), 253 (2000)
Seo SA, Choi HS, Lee DH, Khang G, Lee HB, Polym.(Korea), 25(6), 884 (2001)
Seong H, An TK, Khang G, Choi S, Lee C, Lee HB, Int. J. Pharm., 251, 1 (2003)
Seo KS, Hong KD, Hyun H, Kim MS, Khang G, Lee HB, Tissue Eng. Regen. Med., 2(2), 109 (2005)
Kang GD, Cheon SH, Khang G, Song S, Eur. J. Pharm. Biopharm., 63, 340 (2006)
Kim MS, Hyun H, Seo KS, Cho YH, Lee JW, Lee CR, Khang G, Lee HB, J. Polym. Sci. A: Polym. Chem., 44(18), 5413 (2006)
Kim GY, Tyler BM, Tupper MM, Karp JM, Langer RS, Brem H, Cima MJ, J. Control. Release, 123(2), 172 (2007)
Dang W, Daviau T, Ying P, Zhao Y, Nowotnik D, Clow CS, Tyler B, Brem H, J. Control. Release, 42(1), 83 (1996)
Kim MS, Seong HS, Cho SH, Lee HB, Chae KS, Lee JS, Khang G, Bio-Med. Mater. Eng., 15(3), 229 (2005)
Gopferich A, Tessmar J, Adv. Drug Deliv. Rev., 54, 911 (2002)
Choi HS, Khang G, Shin H, Rhee JM, Lee HB, Int. J. Pharm., 234, 195 (2002)
Ghaderi G, Struesson C, Carlfors J, Int. J. Pharm., 141, 205 (1996)
Park TG, J. Control. Release, 30, 161 (1994)
Iwasaki Y, Sawada S, Nakabayashi N, Khang G, Lee HB, Ishihara K, Biomaterials, 23, 3877 (2002)
Choi BS, Kim SH, Yun SJ, Ha HJ, Kim MS, Yang YI, Son Y, Khang G, Rhee JM, Lee HB, Tissue Eng. Regen. Med., 3(3), 295 (2006)
Gupte A, Ciftci K, Int. J. Pharm., 276(1), 93 (2001)
Fu Y, Shyu S, Su F, Yu P, Colloids Surf. B: Biointerfaces, 25(4), 269 (2002)
Park JS, Shin JH, Lee DH, Rhee JM, Kim MS, Lee HB, Khang G, Polym.(Korea), 31(3), 201 (2007)
Park JS, Lee JH, Choi MG, Rhee JM, Kim MS, Lee HB, Khang G, Polym.(Korea), 31(5), 447 (2007)
Zolnik BS, Burgess DJ, J. Control. Release, 122(3), 338 (2007)
Dunne M, Corrigan OI, Ramtoola Z, Biomaterials, 21(16), 1659 (2000)
Yoo JY, Kim JM, Khang G, Kim MS, Cho SH, Lee HB, Kim YS, Int. J. Pharm., 276, 1 (2004)
