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Received February 22, 2010
Accepted March 24, 2010
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연근 추출물에서 주름개선 소재의 개발
Development of Anti-Wrinkle Agent from Nelumbo nucifera Root Extract
인제대학교 제약공학과, 621-749 경남 김해시 어방동 607번지 1아마란스화장품, 618-817 부산시 강서구 송정동 1534-2
Department of Pharmaceutical Engineering, Inje University, 607, Obang-dong, Gimhae-si, Gyeongnam 621-749, Korea 1Amaranth Cosmetics, 1534-2 Songjung-dong, Gangseo-gu, Busan 618-817, Korea
pedkim@inje.ac.kr
Korean Chemical Engineering Research, August 2010, 48(4), 413-416(4), NONE Epub 8 September 2010
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Abstract
본 연구에서는 연근의 추출물에서 기능성화장품 소재를 개발하고자 하였다. 용매는 70~100%의 에탄올을 이용하였으며, 연근의 유효성분으로 nuciferine을 확인하였다. 연근 추출물의 화장품소재로서의 응용가능성을 보기 위해 안전성시험(MTT assay), 주름개선 효과시험(Elastase 활성저해 시험) 및 항산화효과시험(DPPH free radical scavenging assay) 을 실시하였다. 100% 에탄올로 연근을 추출할 경우 100 μg/ml의 농도에서 세포생존율이 80% 이상이어서 연근 추출물은 화장품소재로서 비교적 안전함을 알 수 있었다. 또한 연근 추출물은 100 μg/ml의 농도에서 elastase 활성억제가 40~50%를 보여주어서 비교적 우수한 주름개선 효과를 나타내었다. 50% 항산화 저해능을 보이는 농도(FSC50)는 5.0~38 μg/ml로 연근 추출물의 항산화효과가 매우 우수하였다. 따라서 연근 에탄올추출물은 주름개선 기능성화장품 소재로서 그 가능성이 높음을 알 수 있었다.
In this research, root extracts of Nelumbo nucifera was tested to see the possibility for functional cosmetic agent. 70-100% ethanol was used as solvent and nuciferin was confirmed as active component. To test cosmetic effect of root extracts of Nelumbo nucifera, safety effect(MTT assay), anti-wrinkle effect(elastase inhibition assay) and antioxidation effect(DPPH free radical scavenging assay) were measured. When 100% ethanol was used as extracting solvent, cell viability was over 80% at 100 μg/ml, which indicated that root extract of Nelumbo nucifera was suitable for cosmetic agent. Root extract of Nelumbo nucifera showed 40~50% elastase inhibition at 100 μg/ml so that it had good antiwrinkle characteristics. 50% antioxidation capacity(FSC50) was 5.0~38 μg/ml and root extract of Nelumbo nucifera showed excellent antioxidation effect. From the research, root extracts of Nelumbo nucifera showed strong possibility for anti-wrinkle functional cosmetic agent.
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Elsner P, Mailbach HI, Cosmeceuticals and Active Cosmetics, 2nd ed., Taylor & Francis, New York, NY (2005)
Lee KH, Park SN, J. Soc. Cosmet. Scientists Korea, 34, 25 (2008)
Yang HJ, Park SN, J. Soc. Cosmet. Scientists Korea, 33, 139 (2007)
Sim GS, Kim JH, Lee DH, Lee BC, Lee GS, Pyo HB, J. Soc. Cosmet. Scientists Korea, 33, 181 (2007)
Kim DH, Choi HK, Cho SC, Kook MC, Park CS, J. Soc. Cosmet. Scientists Korea, 34, 225 (2008)
Pharmacognosy Researchers, Modernpharmacognosy, Hak Chan Publishing, Seoul (2000)
Park JC, Functional Food and Oriental Medicine, Hyoilbooks, Seoul (2007)
Association of Official Analytical Chemists, A.O.A.C., Official Methods of Analysis, 15th ed., Washington DC. (1990)
Mosmann T, J. Immun Method, 65, 55 (1983)
Kim HJ, “Development of Functional Cosmetic Agent from Nelumbo nucifera,” Master Thesis, Inje University, Gimhae, Gyongnam (2009)
Park SK, Hong SK, Kim HJ, Kim BY, Kim T, Kang JS, Kim D, Korean Chem. Eng. Res., 47(5), 553 (2009)
Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea, 33, 165 (2007)
